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Aim: Development and optimization of raloxifene hydrochloride loaded lipid nanocapsule hydrogel for transdermal delivery.

Method: A 3 Box-Behnken Design and numerical optimization was performed to obtain the optimized formulation. Subsequently, the optimized raloxifene hydrochloride loaded lipid nanocapsule was developed using phase inversion temperature and characterized for physicochemical properties.

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The Application of Resolvin D1-Loaded Gelatin Methacrylate in a Rat Periodontitis Model.

Pharmaceutics

December 2024

Department of Clinical Dentistry, Faculty of Health Sciences, UiT the Artic University of Norway, 9037 Tromsø, Norway.

To evaluate the drug release, cytocompatibility with periodontal ligament cells (PDLCs), and therapeutic efficacy of GelMA hydrogel loaded with resolvin D1 (RvD1) in treating rat periodontal inflammation and alveolar bone damage. An RvD1 complexed with GelMA was prepared, and its release kinetics and compatibility with PDLCs were assessed. Rats with induced periodontitis were treated weekly with topical applications of vehicle, GelMA, RvD1, or RvD1 complexed with GelMA for four weeks.

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This review explores the recent advancements and ongoing challenges in regenerating alveolar bone, which is essential for dental implants and periodontal health. It examines traditional techniques like guided bone regeneration and bone grafting, alongside newer methods such as stem cell therapy, gene therapy, and 3D bioprinting. Each approach is considered for its strengths in supporting bone growth and integration, especially in cases where complex bone defects make regeneration difficult.

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Multi-Scale Characterisation and Mechanical Adhesion in PVD-Deposited Ca-SZ Coating for Implantable Medical Devices.

Biomedicines

December 2024

Jean Lamour Institute, Department of Micro and Nanomechanics for Life, University of Lorraine, UMR 7198, 54011 Nancy, France.

Oral implantology faces a multitude of technical challenges in light of current clinical experience, underlining the need for innovation in implantable medical devices in both mechanical and biological terms. This study explores the influence of the thickness factor of calcium-doped zirconia (Ca-SZ) coatings deposited by PVD on their intrinsic mechanical properties and the determinism of the latter on adhesion to the TA6V alloy substrate after mechanical loading for applications in dental implantology. Three separate thicknesses of 250 nm, 450 nm and 850 nm were evaluated in terms of mechanical strength, modulus of elasticity and adhesion to the substrate, in accordance with ISO 20502:2005.

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Introduction: Using digital technology, respectively the use of intraoral scanners has increased exponentially in recent years. Intraoral scanners have gained traction and widespread use in the field of dental prosthetics and orthodontics. While the use of these digital devices enables the detection of visible areas of error in order to allow clinicians to correct those areas immediately without a need of restarting the entire process from the beginning as it should be done in the conventional method and subsequent procedures.

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