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Methylimidazolium ionic liquids - A new class of forever chemicals with endocrine disrupting potential.

Chemosphere

September 2024

Translational and Clinical Research Institute, Level 4 Leech, Newcastle University, Newcastle Upon Tyne, NE2 4HH, United Kingdom. Electronic address:

A class of chemical with a potentially important perceived future contribution to the net zero carbon goal (as "green" solvents) is the methylimidazolium ionic liquids (MILs). These solvents are used in industrial processes such as biofuel production yet little is known about their environmental stability or toxicity in man although one MIL - 1-octyl-3-methylimidazolium (M8OI) - has been shown to activate the human estrogen receptor alpha (ERα). The stabilities of the chloride unsubstituted methylimidazolium (MI) and MILs possessing increasing alkyl chain lengths (2C, 1-ethyl-3-methylimidazolium (EMI); 4C, 1-butyl-3-methylimidazolium (BMI); 6C; 1-hexyl-3-methylimidazolium (HMI), 8C, M8OI; 10C, 1-decyl-3-methylimidazolium (DMI)) were examined in river water and a human liver model system.

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Synthesis and estrogenic activity of BODIPY-labeled estradiol conjugates.

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August 2024

Department of Inorganic, Organic and Analytical Chemistry, University of Szeged, Dóm tér 7‒8 H-6720 Szeged, Hungary; Department of Pharmacognosy, University of Szeged, Eötvös u. 6 H-6720 Szeged, Hungary. Electronic address:

Novel BODIPY-estradiol conjugates have been synthesized by selecting position C-3-O for labeling. The conjugation strategy was based on Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) or etherification. Estradiol derivatives used as azide partners bearing an ω-azidoalkyl function through C-C-long linkers have been prepared.

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Women's Health Update: Growing Role of PET for Patients with Breast Cancer.

Semin Nucl Med

March 2024

Nuclear Medicine-Radiopharmacology, Champalimaud Clinical Center, Champalimaud Foundation, Lisbon, Portugal; Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.

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  • PET scans are becoming more popular for breast cancer patients because there are more approved types that help doctors see how the cancer is doing.
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Biopharmaceuticals, including therapeutic antibodies, are rapidly growing products in the pharmaceutical market. Mammalian cells, such as Chinese hamster ovary (CHO) cells, are widely used as production hosts because recombinant antibodies require complex three-dimensional structures modified with sugar chains. Recombinant protein production using mammalian cells is generally performed with cell growth.

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Nuclear receptor superfamily structural diversity in pacific oyster: In silico identification of estradiol binding candidates.

Chemosphere

November 2023

Programa de Pós-Graduação Em Bioquímica, Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Laboratório de Biomarcadores de Contaminação Aquática e Imunoquímica, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-900, Brazil. Electronic address:

The increasing presence of anthropogenic contaminants in aquatic environments poses challenges for species inhabiting contaminated sites. Due to their structural binding characteristics to ligands that inhibit or activate gene transcription, these xenobiotic compounds frequently target the nuclear receptor superfamily. The present work aims to understand the potential interaction between the hormone 17-β-estradiol, an environmental contaminant, and the nuclear receptors of Crassostrea gigas, the Pacific oyster.

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