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In-silico method development and optimization of on-line comprehensive two-dimensional liquid chromatography via a shortcut model.
J Chromatogr A
April 2024
Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. Electronic address:
Comprehensive two-dimensional liquid chromatography (LCxLC) represents a valuable alternative to conventional single column, or one-dimensional, liquid chromatography (1D-LC) for resolving multiple components in a complex mixture in a short time. However, developing LCxLC methods with trial-and-error experiments is challenging and time-consuming, which is why the technique is not dominant despite its significant potential. This work presents a novel shortcut model to in-silico predicting retention time and peak width within an RPLCxRPLC separation system (i.
View Article and Find Full Text PDFHigh-Linearity and High-Speed ROIC of Ultra-Large Array Infrared Detectors Based on Adaptive Compensation and Enhancement.
Sensors (Basel)
June 2023
Department of Electronic Engineering, Xi'an University of Technology, No. 5, Jinhua South Road, Xi'an 710054, China.
In order to solve the problem of limited linearity and frame rate in the large array infrared (IR) readout integrated circuit (ROIC), a high-linearity and high-speed readout method based on adaptive offset compensation and alternating current (AC) enhancement is proposed in this paper. The efficient correlated double sampling (CDS) method in pixels is used to optimize the noise characteristics of the ROIC and output CDS voltage to the column bus. An AC enhancement method is proposed to quickly establish the column bus signal, and an adaptive offset compensation method is used at the column bus terminal to eliminate the nonlinearity caused by the pixel source follower (SF).
View Article and Find Full Text PDFValidation and optimization of viral clearance in a downstream continuous chromatography setting.
Biotechnol Bioeng
September 2019
Biotechnology Process Research and Development, Pall Biotech, Westborough, Massachusetts.
Continuous bioprocessing holds the potential to improve product consistency, accelerate productivity, and lower cost of production. However, switching a bioprocess from traditional batch to continuous mode requires surmounting business and regulatory challenges. A key regulatory requirement for all biopharmaceuticals is virus safety, which is assured through a combination of testing and virus clearance through purification unit operations.
View Article and Find Full Text PDFAmericium and plutonium separation by extraction chromatography for determination by accelerator mass spectrometry.
Anal Chim Acta
June 2014
Department of Physics, University of Ottawa, 140 Louis Pasteur Avenue, Ottawa K1N 6N5, Canada.
A simple method was developed to separate Pu and Am using single column extraction chromatography employing N,N,N',N'-tetra-n-octyldiglycolamide (DGA) resin. Isotope dilution measurements of Am and Pu were performed using accelerator mass spectrometry (AMS) and alpha spectrometry. For maximum adsorption Pu was stabilized in the tetra valent oxidation state in 8M HNO3 with 0.
View Article and Find Full Text PDFProbe integrated scattering cross sections in the analysis of atomic resolution HAADF STEM images.
Ultramicroscopy
October 2013
Department of Materials, Oxford University, Parks Road, Oxford OX1 3PH, UK.
The physical basis for using a probe-position integrated cross section (PICS) for a single column of atoms as an effective way to compare simulation and experiment in high-angle annular dark-field (HAADF) scanning transmission electron microscopy (STEM) is described, and the use of PICS in order to make quantitative use of image intensities is evaluated. It is based upon the calibration of the detector and the measurement of scattered intensities. Due to the predominantly incoherent nature of HAADF STEM, it is found to be robust to parameters that affect probe size and shape such as defocus and source coherence.
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