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Importance: Stereotactic body radiation therapy (SBRT) for spinal metastases improves symptomatic outcomes and local control compared to conventional radiotherapy. Treatment failure most often occurs within the epidural space, where dose is constrained by the risk of radiation myelitis (RM). Current constraints designed to prevent RM after spine SBRT are derived from limited data.

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Presents an overview of domestic and foreign sources on the diagnosis of neuroinfections in children of different etiologies based on epidemiological, physical, cerebrospinal fluid, etiological, radiation and other methods. Their combination makes it possible to establish the syndrome of neuroinfection (meningitis, encephalitis, myelitis, polyradioloneuritis, etc.), the severity, the presence of complications, the nature of the course, etiology.

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Reirradiation of bone metastasis: A narrative review of the literature.

Cancer Radiother

November 2024

Radiation Department, Institut de cancérologie de Lorraine, 54519 Vandœuvre-Lès-Nancy, France.

Article Synopsis
  • - Patients with bone metastasis often undergo palliative radiotherapy, with about 20% needing reirradiation to manage symptoms or control local progression of cancer lesions.
  • - Around two-thirds of patients experience pain relief from bone reirradiation, but spinal cord damage presents a risk, particularly with cumulative doses over 50 Gy.
  • - Effective reirradiation requires careful planning, a multidisciplinary team approach, assessing alternative treatment options, and ensuring that patients are monitored closely after the procedure.
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A 78-year-old woman with a history of breast cancer, melanoma, and radiation therapy presented with worsening chronic osteomyelitis and radiation necrosis of her clavicle, scapula, and upper ribs. Despite treatment with vancomycin, she experienced significant lymphedema and near-total loss of motor function in the left upper extremity. Given the progression of the disease and diminished functionality of the limb, a forequarter amputation was determined to be the only viable option beyond supportive care.

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