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Iatrogenic Aortic Dissection During Catheter Ablation for Ventricular Arrhythmia.
Heart Rhythm
March 2025
Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Attempted catheter manipulation via the retrograde aortic approach carries a risk of aortic dissection (AD) during catheter ablation.
Objective: To determine the incidence, management, and outcomes of iatrogenic AD associated with ablation of ventricular arrhythmia (VA).
Methods: All patients who sustained iatrogenic AD during retrograde aortic VA ablation at 6 centers between January 1, 2011 and September 30, 2023 were prospectively identified.
(Porifera) Is Highly Resistant to Radiation Exposure and Possibly Cancer.
Biology (Basel)
February 2025
Arizona Cancer Evolution Center, Arizona State University, Tempe, AZ 85287, USA.
There are no reports of cancer in sponges, despite them having somatic cell turnover, long lifespans, and no specialized adaptive immune cells. In order to investigate whether sponges are cancer resistant, we exposed a species of sponge, , to X-rays. We found that can withstand 518 Gy of X-ray radiation.
View Article and Find Full Text PDFA new Drosophila melanogaster research resource: CRISPR-induced mutations for clonal analysis of fourth chromosome genes.
G3 (Bethesda)
January 2025
School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA.
As part of an ongoing effort to generate comprehensive resources for the experimental analysis of fourth chromosome genes in Drosophila melanogaster, the Fourth Chromosome Resource Project has used CRISPR mutagenesis with single guide RNAs to isolate mutations in 62 of the 80 fourth chromosome, protein-coding genes. These mutations were induced on a fourth chromosome bearing a basal FRT insertion to facilitate experimental approaches involving FLP recombinase-induced mitotic recombination. To permit straightforward comparisons among mutant stocks, most of the mutations were generated on isogenic fourth chromosomes, which were then crossed into a common genetic background.
View Article and Find Full Text PDFSingle-cell RNA sequencing reveals intrahepatic signature related to pathobiology of duck hepatitis A virus type 3 (DHAV-3) infection.
Poult Sci
February 2025
College of Animal Science and Technology, Northwest A&F University, Yangling 712100 Shaanxi, PR China. Electronic address:
DHAV-3 is one of the main causative agents of duck viral hepatitis (DVH), an acute and highly lethal infectious disease in duck industry. However, the understanding of the pathogenesis of this virus in ducklings is limited. To dissect the molecular characteristics associated with pathobiology of ducklings to DHAV-3, we applied single-cell RNA-sequencing approach to profile the transcriptome of 1.
View Article and Find Full Text PDFCombined Solid Organ Transplant and Transfusion-Associated Graft-Versus-Host Disease in a Lung Transplant Recipient: An Uncertain Culprit With Lethal Complications.
Case Rep Transplant
December 2024
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA.
Although graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplantation, it is rare after solid organ transplantation (SOT) or blood transfusion. We present a rare case of SOT-derived and/or transfusion-associated graft-versus-host disease (TA-GVHD) in a 66-year-old man with interstitial lung disease who underwent bilateral lung transplantation (LT) from a 12-year-old female donor and required three units of packed red blood cells intraoperatively. He presented with signs and symptoms consistent with GVHD, and a bone marrow biopsy revealed an XX karyotype.
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