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Long-Term Prognostic Implications of Non-Culprit Lesions in Patients Presenting With an Acute Myocardial Infarction: Is It the Angiographic Stenosis Severity or the Underlying High-Risk Morphology?
Circulation
January 2025
Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China (J.D., J.Z., X.X., Y.C., S.S., S.L., L.C., Y.W., L.L., R.G., D.H., X.M., R.Z., H.Y., T.C., J.T., X.L., S.J., J.H., C.F.B.Y.).
Background: Patients with acute myocardial infarction and angiographically obstructive non-culprit lesions are at high risk for recurrent major adverse cardiac events (MACEs). However, it remains largely unknown whether events are due to stenosis severity or due to the underlying high-risk lesion morphology.
Methods: Between January 2017 and December 2021, 1312 patients with acute myocardial infarction underwent optical coherence tomography of all the 3 main epicardial arteries after successful percutaneous coronary intervention.
Remote Ischemic Conditioning Attenuates Transneuronal Degeneration and Promotes Stroke Recovery via CD36-Mediated Efferocytosis.
Circ Res
January 2025
Burke Neurological Institute, White Plains, NY (H.J., I.P., K.W.P., J.M., A.M., S.C.).
Background: Remote ischemic conditioning (RIC) has been implicated in cross-organ protection in cerebrovascular disease, including stroke. However, the lack of a consensus protocol and controversy over the clinical therapeutic outcomes of RIC suggest an inadequate mechanistic understanding of RIC. The current study identifies RIC-induced molecular and cellular events in the blood, which enhance long-term functional recovery in experimental cerebral ischemia.
View Article and Find Full Text PDFCoronary Myocardial Bridge Updates: Anatomy, Pathophysiology, Clinical Manifestations, Diagnosis, and Treatment Options.
Tex Heart Inst J
January 2025
Center for Women's Heart and Vascular Health, The Texas Heart Institute, Houston, Texas.
Myocardial bridging is a frequent anomaly of the heart in humans and other animals. A myocardial bridge is typically characterized by the systolic narrowing seen with traditional catheter angiography, but this abnormality is not by itself a sign of ischemia or the need for intervention. In particular, transient spontaneous angina must be corroborated by reproducible narrowing during acetylcholine testing; this narrowing occurs during resting conditions and is responsive to nitroglycerin administration.
View Article and Find Full Text PDFWhat Are These Anterior T Waves?: A High-Risk Ischemic Pattern That Should Be Recognized.
JACC Case Rep
January 2025
Cardiology Department, University Hospital Doctor Negrín, Las Palmas de Gran Canaria, Spain.
An 80-year-old woman with history of intermittent chest pain presented with a new self-limited episode. A 12-lead electrocardiogram was performed while she was asymptomatic, showing large T waves in V to V. We report a not so known electrocardiographic pattern that can be particularly valuable for identifying patients at high risk of extensive myocardial infarction and its subsequent complications.
View Article and Find Full Text PDFUltra-High-Density Catheter Ablation of Purkinje Premature Ventricular Contractions Causing Electrical Storm.
JACC Case Rep
January 2025
Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.
The postacute myocardial infarction electrical storm is a life-threatening entity. Resistance to ischemia in Purkinje fibers may be the origin of short-coupled premature ventricular contractions that trigger severe arrhythmic events. We present a case where the use of emergency catheter ablation, guided by a 3D navigation system and an ultra-high-density mapping catheter, successfully terminated the arrhythmic storm.
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