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On the Role of Epigenetic Modifications of HPA Axis in Post Traumatic Stress Disorder (PTSD) and Resilience.
J Neurophysiol
January 2025
Department of Family Medicine, Cumming School of Medicine; University of Calgary; Calgary, Alberta, T2N 1N4; Canada.
Stress is a fundamental adaptive response mediated by the amygdala and Hypothalamus-Pituitary-Adrenal (HPA) axis. Extreme or chronic stress, however, can result in a multitude of neuropsychiatric disorders, including anxiety, paranoia, bipolar disorder (BP), major depressive disorder (MDD), and Post-Traumatic Stress Disorder (PTSD). Despite widespread exposure to trauma (70.
View Article and Find Full Text PDFOverexpression of FTO alleviates traumatic brain injury induced posttraumatic epilepsy by upregulating NR4A2 expression via m6A demethylation.
Funct Integr Genomics
January 2025
Department of Radiology, The Second Xiangya Hospital of Central South University, No. 139, Renmin Middle Road, Furong District, Changsha City, Hunan Province, 410011, China.
Post-traumatic epilepsy (PTE) is a debilitating chronic outcome of traumatic brain injury (TBI). Although FTO has been reported as a possible intervention target of TBI, its precise roles in the PTE remain incompletely understood. Here we used mild or serious mice TBI model to probe the role and molecular mechanism of FTO in PTE.
View Article and Find Full Text PDFIndirect Effects of Childhood Maltreatment on Posttraumatic Stress Disorder Symptoms via Emotion Regulation Difficulties.
Violence Vict
January 2025
Department of Psychology, University of South Dakota, Vermillion, SD, USA.
This study tested structural equation models of associations between childhood maltreatment (CM), posttraumatic stress disorder (PTSD) symptoms, and emotion regulation (ER) difficulties in a sample of young adult college students ( = 606). The primary final model demonstrated that lack of emotional clarity and limited access to ER strategies partially mediated the association between CM and PTSD symptoms. Exploratory analyses showed that CM was also indirectly associated with PTSD symptoms via lack of emotional awareness, nonacceptance, and difficulty controlling impulses.
View Article and Find Full Text PDFReverse shoulder arthroplasty in revision surgery-Indications and results.
PLoS One
January 2025
Division of Arthroscopic and special Joint Surgery / Sports Injuries, Department of Orthopedics, Trauma and Plastic Surgery, University of Leipzig, Leipzig, Germany.
Background: The number of reverse shoulder arthroplasty (RSA) procedures performed worldwide has increased over the last 10 years, with a corresponding increase in revision shoulder arthroplasty (SRSA). SRSA is often used for post-traumatic revision surgery in cases of infections and failure of anatomical prostheses. Data on outcomes with specific detail for each indication for the prosthetic solution as a secondary treatment are scarce, and inhomogeneous.
View Article and Find Full Text PDFHippocampal SIRT1 signaling mediates the ameliorative effect of treadmill exercise on anxiety- and depression-like behavior in APP/PS1 mice.
Front Aging Neurosci
December 2024
Scientific Research Center, Guangzhou Sport University, Guangzhou, China.
Objective: Anxiety and depression-like symptoms occur in the early stages of Alzheimer's disease. Hippocampal Sirtuin 1 (SIRT1) signaling mediates anxiety- and depression-like behavior. Exercise training improves anxiety and depression-like behavior in various disease models, such as the rat chronic restraint stress model, rat model of posttraumatic stress disorder, and rat model of fetal alcohol spectrum disorders.
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