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Serum Albumin Assessment in Neonatal Jaundice: Impact on Phototherapy Decision-Making.
Hosp Pediatr
January 2025
Ramathibodi Medical School, Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.
Article Synopsis
- The study aimed to examine how serum albumin levels influence treatment decisions for early neonatal jaundice in infants admitted to hospitals in Thailand.
- A total of 935 infants were reviewed, with 26.7% showing low serum albumin levels (<3.0 g/dL), but this had a minimal effect on the decisions regarding phototherapy treatment.
- Ultimately, the presence of low serum albumin only influenced phototherapy treatment in 1.7% of the infants, indicating that while low levels are common, they rarely change treatment protocols.
Comparison of Efficacy and Safety Outcomes of Different Doses Schedules of Thalidomide for Treating Moderate-to-Severe β-Thalassemia Patients.
Ther Clin Risk Manag
November 2024
Department of Eugenics and Genetics, Guilin People's Hospital, Guilin, Guangxi Zhuang Autonomous Region, 541002, People's Republic of China.
Objective: In this study, we evaluated the effectiveness and safety of thalidomide by clinically observing 48 individuals with β-thalassemia who have been administered thalidomide in small and medium doses over a period of two years.
Methods: Thalidomide's efficacy was gauged by tracking hemoglobin (Hb) level alterations post its administration. Liver and kidney function impact was measured through tests for alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, and creatinine.
Visualization of Unconjugated Bilirubin In Vivo with a Novel Approach Using Chemical Exchange Saturation Transfer Magnetic Resonance Imaging in a Rat Model.
ACS Chem Neurosci
December 2024
Department of Radiology, The Second Affiliated Hospital, Medical College of Shantou University, Shantou 515041, China.
Unconjugated bilirubin (UCB) visualization is valuable for early bilirubin encephalopathy (BE) diagnosis and management. UCB neurotoxicity is a challenge, necessitating improved imaging modalities for precise localization and characterization. This study developed a noninvasive method for UCB imaging in the brain using chemical exchange saturation transfer (CEST) magnetic resonance imaging, which visualizes UCB distribution through amide-bulk water proton exchange, a process termed bilirubin CEST (Bil-CEST) imaging.
View Article and Find Full Text PDFHepatoprotective and neuroprotective effects of quinacrine against bile duct ligation-induced hepatic encephalopathy in rats: Role of bone morphogenetic proteins signaling.
Life Sci
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:
Article Synopsis
- The study evaluated quinacrine, an FDA-approved drug, for its protective effects against hepatic encephalopathy (HE) in a rat model with bile duct ligation (BDL) and focused on the liver-brain communication through BMP2 signaling.
- Results indicated that BDL caused significant liver damage and cognitive deficits in rats, but quinacrine treatment improved liver function and cognitive abilities by restoring crucial signaling pathways.
- The findings suggest that quinacrine may offer potential benefits for treating HE by enhancing liver and brain health, highlighting the role of BMP2 signaling in this process.*
The U-shaped association between serum direct bilirubin and incident mild cognitive impairment in hemodialysis patients: a multicenter study.
BMC Psychiatry
October 2024
Department of Nephrology, Guizhou Provincial People's Hospital, Zhongshan Dong Road No. 83, Guiyang, Guizhou, 550002, China.
Background: Previous studies have suggested an association between low serum bilirubin concentrations and increased risk of cognitive impairment. This study aimed to explore the association and dose-response relationship between serum direct bilirubin (DBIL) concentrations and mild cognitive impairment (MCI) among hemodialysis patients.
Methods: This is a multicenter cross-sectional study with patients undergoing hemodialysis from 22 dialysis centers in Guizhou Province, China.
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