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[Establishment of Nano-ITO induced rat model of indium lung disease and exploration of its pathological characteristics].
Zhonghua Jie He He Hu Xi Za Zhi
September 2024
School of Public Health, North China University of Science and Technology, Hebei Key Laboratory of Occupational Health and Safety for Coal Industry, Tangshan 063210, China.
Article Synopsis
- The study investigates the effects of Nano-ITO on lung tissue in rats to better understand indium lung disease, focusing on pulmonary interstitial injury and pulmonary alveolar proteinosis (PAP).
- Experiments included dose-response and time-course studies, analyzing cytokine levels and oxidative stress in bronchoalveolar lavage fluid, as well as various staining techniques for lung tissue pathology.
- Findings revealed three stages of lung injury: acute inflammation after 3 days, granuloma formation and collagen hyperplasia by 14 days, and alveolar proteinosis developing at 56 days post-exposure, highlighting significant cellular changes and pathological features in lung tissues.
Background: Extracellular vesicles are surrounded by a phospholipid bilayer, carrying various active biomolecules and participating in many physiological and pathological processes, including infectious ones.
Objective: To research the role of exosomes in intercellular interactions in the pathogenesis of various types of lung damage in fatal cases of COVID-19.
Material And Methods: We conducted a clinical and morphological analysis of 118 fatal cases caused by coronavirus infection in Moscow.
Correlation between Neutrophil Extracellular Traps (NETs) Expression and Primary Graft Dysfunction Following Human Lung Transplantation.
Cells
October 2022
Research Center-Montreal Heart Institute, 5000 Belanger St., Montreal, QC H1T 1C8, Canada.
Primary graft dysfunction (PGD) is characterized by alveolar epithelial and vascular endothelial damage and inflammation, lung edema and hypoxemia. Up to one-third of recipients develop the most severe form of PGD (Grade 3; PGD3). Animal studies suggest that neutrophils contribute to the inflammatory process through neutrophil extracellular traps (NETs) release (NETosis).
View Article and Find Full Text PDFPulmonary papillary adenoma with malignant potential: a case report and literature review.
Diagn Pathol
October 2022
Department of Pathology, Luzhou People's Hospital, Jiangyang District, 646000, Luzhou, Sichuan Province, People's Republic of China.
Background: Pulmonary papillary adenoma is a rare benign tumor in the periphery of the lung. We report a 66-year-old female patient with a tumor in the lower lobe of the right lung and present the clinicopathological features and review the literature.
Case Presentation: A tumor in the lower lobe of the right lung was found incidentally on chest X-ray during the physical examination of the patient, and the patient occasionally had a dry cough that was not treated.
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infection.
Nat Commun
October 2021
CIRI, Centre International de Recherche en Infectiologie, Team Immunobiology of the Viral infections, Univ Lyon, Inserm, U1111, CNRS, UMR5308, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, LYON, France.
SARS-CoV-2 has caused a global pandemic of COVID-19 since its emergence in December 2019. The infection causes a severe acute respiratory syndrome and may also spread to central nervous system leading to neurological sequelae. We have developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offer a unique opportunity to study the early steps of viral infection and screening antivirals.
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