Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/ar.1091730110 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Single-cell profiling of the amphioxus digestive tract reveals conservation of endocrine cells in chordates.
Sci Adv
December 2024
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
Despite their pivotal role, the evolutionary origins of vertebrate digestive systems remain enigmatic. We explored the cellular characteristics of the amphioxus () digestive tract, a model for the presumed primitive chordate digestive system, using bulk tissue companioned with single-cell RNA sequencing. Our findings reveal segmentation and a rich diversity of cell clusters, and we highlight the presence of epithelial-like, ciliated cells in the amphioxus midgut and describe three types of endocrine-like cells that secrete insulin-like, glucagon-like, and somatostatin-like peptides.
View Article and Find Full Text PDFHybrid Micro-/Nanoprotein Platform Provides Endocrine-like and Extracellular Matrix-like Cell Delivery of Growth Factors.
ACS Appl Mater Interfaces
July 2024
Institut de Biotecnologia i de Biomedicina (IBB), Universitat Autònoma de Barcelona, Barcelona 08193, Spain.
Protein materials are versatile tools in diverse biomedical fields. Among them, artificial secretory granules (SGs), mimicking those from the endocrine system, act as mechanically stable reservoirs for the sustained release of proteins as oligomeric functional nanoparticles. Only validated in oncology, the physicochemical properties of SGs, along with their combined drug-releasing and scaffolding abilities, make them suitable as smart topographies in regenerative medicine for the prolonged delivery of growth factors (GFs).
View Article and Find Full Text PDFRare, Tightly-Bound, Multi-Cellular Clusters in the Pancreatic Ducts of Adult Mice Function Like Progenitor Cells and Survive and Proliferate After Acinar Cell Injury.
Stem Cells
April 2024
Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.
Pancreatic ductal progenitor cells have been proposed to contribute to adult tissue maintenance and regeneration after injury, but the identity of such ductal cells remains elusive. Here, from adult mice, we identify a near homogenous population of ductal progenitor-like clusters, with an average of 8 cells per cluster. They are a rare subpopulation, about 0.
View Article and Find Full Text PDFExtracellular and intracellular functions of coiled-coil domain containing 3.
J Mol Cell Biol
November 2023
Department of Biochemistry & Molecular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Article Synopsis
- CCDC3 (or Favine) is a conserved protein known for its secretion from fat and blood vessel cells, exhibiting endocrine-like functions.
- Recently, it has been identified as a nuclear tumor suppressor, particularly in breast cancer, indicating its diverse roles in health and disease.
- The essay explores CCDC3's functions in areas like lipid metabolism and obesity, discusses potential mechanisms and clinical implications, and highlights ongoing research gaps regarding this molecule.
A matrigel-free method for culture of pancreatic endocrine-like cells in defined protein-based hydrogels.
Front Bioeng Biotechnol
March 2023
Department of Translational Research and Cellular Therapeutics, Arthur Riggs Diabetes and Metabolism Research Institute and Beckman Research Institute of City of Hope, Duarte, CA, United States.
The transplantation of pancreatic endocrine islet cells from cadaveric donors is a promising treatment for type 1 diabetes (T1D), which is a chronic autoimmune disease that affects approximately nine million people worldwide. However, the demand for donor islets outstrips supply. This problem could be solved by differentiating stem and progenitor cells to islet cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!