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Pharmacokinetics and absorption, distribution, metabolism and excretion profiling of tanimilast following an intravenous C-microtracer coadministered with an inhaled dose in healthy male individuals.
Drug Metab Dispos
January 2025
Global Clinical Development, Chiesi Farmaceutici SpA, Parma, Italy.
Tanimilast is an inhaled phosphodiesterase-4 inhibitor currently in phase III clinical development for treating chronic obstructive pulmonary disease and asthma. This trial aimed to characterize the pharmacokinetics, mass balance, and metabolite profiling of tanimilast. Eight healthy male volunteers received a single dose of nonradiolabeled tanimilast via powder inhaler (Chiesi NEXThaler [3200 μg]), followed by a concomitant intravenous infusion of a microtracer ([C]-tanimilast: 18.
View Article and Find Full Text PDFCOMPARING MESH AND COMPRESSOR NEBULIZERS IN PULMONARY FUNCTION TEST IN PEDIATRIC ASTHMA ATTACKS: A DOUBLE-BLIND RANDOMIZED COMPARATIVE CLINICAL TRIAL.
Respir Med
January 2025
Celal Bayar University, Faculty of Medicine, Department Pediatric Allergy and Immunology, Manisa, Turkey.
Objective: Asthma is a prevalent global health issue, especially affecting children in numerous countries. Our study aimed to determine the most effective nebulizer type by comparing the effects of mesh nebulizers (MNs) and compressor nebulizers (CNs) on spirometry tests in pediatric asthma attacks.
Methods: The prospective, double-blind, randomized comparative study was conducted with patients aged 7-15 presenting with asthma attacks.
Green Approach for Simultaneous Determination of Long Acting β-Agonists, their Organic Counterparts and Corticosteroids by HPLC Coupled with PDA Detector.
Ann Pharm Fr
January 2025
Department of Pharmaceutical Quality Assurance, SSR College of Pharmacy, Sayli Road, Silvassa, UT of Dadra and Nagar Haveli-396 230, India. Electronic address:
Objective: Accurate, precise and robust method was developed for the simultaneous estimation of long acting β2 agonist drugs (Formoterol fumarate, Salmeterol xinafoate and Vilanterol trifenatate) along with two organic counterparts (Xinafoic acid and Triphenyl acetic acid) and inhaled corticosteroids (Fluticasone propionate and Fluticasone furoate).
Material And Methods: The separation was carried out using C column (250 x 4.6 mm, 5 μ) with eluent comprising of 0.
Respiratory influence on cerebral blood flow and blood volume - A 4D flow MRI study.
J Cereb Blood Flow Metab
January 2025
Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden.
Variations in cerebral blood flow and blood volume interact with intracranial pressure and cerebrospinal fluid dynamics, all of which play a crucial role in brain homeostasis. A key physiological modulator is respiration, but its impact on cerebral blood flow and volume has not been thoroughly investigated. Here we used 4D flow MRI in a population-based sample of 65 participants (mean age = 75 ± 1) to quantify these effects.
View Article and Find Full Text PDFNot too much, not too little. Titrating flow rate to minimise inspiratory effort during helmet CPAP: A bench study.
Pulmonology
December 2025
Department of Emergency and Intensive Care, Fondazione IRCCS San Gerardo dei tintori, Monza, Italy.
Background: Non-invasive helmet respiratory support is suitable for several clinical conditions. Continuous-flow helmet CPAP systems equipped with HEPA filters have become popular during the recent Coronavirus pandemic. However, HEPA filters generate an overpressure above the set PEEP.
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