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Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory.
Nat Cardiovasc Res
March 2025
State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, The Second Hospital of Tianjin Medical University, Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin, China.
Maternal exposure to a Western-type diet (WD) increases the susceptibility of adult offspring to atherosclerosis, partly because fetal endothelial cells (ECs) become dysfunctional and inflamed due to risk factors transmitted via maternal-fetal blood exchange. However, the underlying mechanisms remain unclear. Here we show that maternal WD accelerates atherogenesis in adult offspring mice by regulating chromatin dynamics through activator protein-1 (AP-1) in aortic ECs, inducing inflammatory memory at the chromatin level.
View Article and Find Full Text PDFMultiple pyrazolyazoindole/indazoles scaffolds-based visible-light photoswitches with versatile controlled photophysical properties.
Mol Divers
March 2025
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, 210094, Jiangsu, China.
Azoheteroarenes-based photoswitches with high bidirectional isomerization and long thermal half-life (t) have attracted widespread attention from researchers. The diversity of molecular scaffolds has a profound impact on photoswitching performance, herein, we incorporated dynamic connection sites and scaffold optimization to construct a series of pyrazolyazoindole/indazoles (PAIs)-based photoswitches with adjustable photoswitching properties and versatile photophysical properties upon the irradiation of special wavelength, among them 4Z-H can be switched between states "lock" and "unlock" by Cu ion and EDTA. Thermal stability of series 3Z and 4Z was more stable than other PAIs photoswitches for their intramolecular forces, while the steric effect weakened the thermal stability of series 5D, these results clarified the relationship between the PAIs scaffolds and their photoswitching properties.
View Article and Find Full Text PDFMulticlass Determination of 87 Mixed Veterinary Drugs, Pesticides and Mycotoxin Residues in Beef Muscle Samples by Ionic Liquid-Based Dispersive Liquid-Liquid Microextraction and Liquid Chromatography Tandem Mass Spectrometry.
Foods
February 2025
Institute for Nanotechnology and Water Sustainability (iNanoWS), The Science Campus, College of Science, Engineering and Technology (CSET), University of South Africa, Florida Park, Roodepoort, South Africa.
A miniaturised, eco-friendly and efficient multiclass method for the simultaneous determination of 87 veterinary drugs, pesticides and mycotoxin residues in beef muscle samples by ionic liquid-based dispersive liquid-liquid microextraction (IL-DLLME) and liquid chromatography tandem mass spectrometry (LC-MS/MS) was developed and validated according to Commission Implementing Regulation (EU) 2021/808 and ISO/IEC 17025: 2017. Under IL-DLLME optimum conditions, matrix calibration yielded a coefficient of determination () ranging from 0.99942 to 0.
View Article and Find Full Text PDFCoupled Influence of Magnetic Biochar and Solution Chemistries on Retention and Release of Nanoplastics in Porous Media.
Int J Mol Sci
February 2025
School of Resources, Environment and Materials, Guangxi University, Nanning 530004, China.
Magnetic biochar (MBC), as an environmentally friendly material, has been extensively used for the remediation of soil and groundwater contamination. The retention and release of nanoplastics (NPs) with carboxyl (NPs-COOH) or amino functionalization (NPs- NH) in saturated porous media were investigated under varying conditions of ionic strength (IS), MBC addition, humic acid (HA) concentration, and cation types. The reversible and irreversible retention of NPs was examined by altering the IS, increasing the solution pH, and inducing cation exchange.
View Article and Find Full Text PDFOptimization of Surfactant-Mediated Green Extraction of Phenolic Compounds from Grape Pomace Using Response Surface Methodology.
Int J Mol Sci
February 2025
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Grape pomace is a by-product abundant in phenolic compounds that can be used in the food, cosmetic, and pharmaceutical industries. For the efficient extraction of such compounds, an aqueous solution of non-ionic surfactant Brij S20 was applied as a green extraction medium, and the optimization was performed using surface response methodology. The effects of four independent factors (surfactant concentration, time, pH, and solvent-to-material ratio) were evaluated, and total phenolic content (TPC), DPPH radical inhibition, and selected polyphenol compound concentrations were analyzed as responses.
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