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Health impacts of a remotely delivered prolonged nightly fasting intervention in stressed adults with memory decline and obesity: A nationwide randomized controlled pilot trial.
J Clin Transl Sci
November 2024
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Objective/goals: Cognitive decline is intricately linked to various factors such as obesity, stress, poor sleep, and circadian rhythm misalignment, which are interrelated in their impact on cognitive health. Irregular food-intake timing further compounds these issues. The practice of prolonged nightly fasting (PNF) may help synchronize food intake with circadian rhythms, potentially mitigating adverse effects of cognitive decline and associated factors.
View Article and Find Full Text PDFThe role of clock control of DRP1 activity involved in postoperative cognitive dysfunction.
Exp Neurol
January 2025
School of Public Health, Nanjing Medical University, Nanjing 211166, China. Electronic address:
Postoperative cognitive dysfunction (POCD) is a prevalent clinical issue following anesthesia and surgery. The onset of POCD, which is closely linked to circadian rhythm disturbance in previous studies, yet the underlying mechanism remains elusive. There is increasing evidence showed that mitochondrial architecture is coordinated by the circadian clock which DRP1 playing a crucial role.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South).
Background: Brain volume is influenced by several factors that can change throughout the day. In addition, most of these factors are influenced by sleep quality. This study investigated diurnal variation in brain volume and its relation to overnight sleep quality.
View Article and Find Full Text PDFBackground: Circadian function, characterized by circadian strength, timing, and fragmentation, has been shown to correlate with cognitive function; however, little is known about in these associations, particularly among older adults who may have more variability in their sleep-wake schedules.
Method: Among 60 community-living adults aged 60-90 years with self-reported sleep complaints ≥once/ week, we investigated gender differences in the associations between circadian and cognitive function. Participants completed seven days of actigraphy and one night of polysomnography.
Biomarkers.
Alzheimers Dement
December 2024
Sorbonne University, GRC n°21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Boulevard de L'hôpital, F-75013, Paris, France.
Background: Neuropsychiatric symptoms (NPS), including depression and circadian rhythm disruptions, are early non-cognitive markers along the Alzheimer's Disease (AD) continuum. These pathological states are thought to resemble AD pathogenesis, both of which are characterized by a marked decline in adult hippocampal neurogenesis.
Method: 96 elderly participants divided into three groups based on the global depression scale, neuropsychiatric inventory, clinical dementia rating, and mini-mental status examination.
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