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New insights into butyrylcholinesterase: Pharmaceutical applications, selective inhibitors and multitarget-directed ligands.
Eur J Med Chem
September 2024
School of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. Electronic address:
Article Synopsis
- * Recent studies have shown that BChE levels can increase in Alzheimer's, and using BChE inhibitors may improve cognitive function and other symptoms in animal models.
- * There are exciting new strategies for creating BChE inhibitors, especially ones that combine targeting multiple proteins, which may help in treating Alzheimer's and possibly in managing lipid metabolism disorders.
Exploring the composition and properties of Centella asiatica metabolites and investigating their impact on BSA glycation, LDL oxidation and α-amylase inhibition.
J Pharm Biomed Anal
August 2024
Laboratory of Biochemistry and Molecular Biology in Institute of Biotechnology, Federal University of Uberlândia, Uberlândia, MG 38400-902, Brazil. Electronic address:
Centella asiatica (L.) Urb. is a small herbaceous plant belonging to the Apiaceae family that is rich in triterpenes, such as asiaticoside and madecassoside.
View Article and Find Full Text PDFNew paradigms in the study of the cholinergic system and metabolic diseases: Acetyl-and-butyrylcholinesterase.
J Cell Physiol
August 2024
Laboratorio en Biología del Desarrollo, Unidad de Morfología y Función, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Estado de México, México.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are enzymes that belong to the neuromuscular cholinergic system, their main function is to hydrolyze the neurotransmitter acetylcholine (ACh), through their hydrolysis these enzymes regulate the neuronal and neuromuscular cholinergic system. They have recently attracted considerable attention due to the discovery of new enzymatic and nonenzymatic functions. These discoveries have aroused the interest of numerous scientists, consolidating the relevance of this group of enzymes.
View Article and Find Full Text PDFOnset of Alzheimer disease in apolipoprotein ɛ4 carriers is earlier in butyrylcholinesterase K variant carriers.
BMC Neurol
April 2024
Dementia Research Centre, Institute of Neurology, London, UK.
Background: The authors sought to examine the impact of the K-variant of butyrylcholinesterase (BCHE-K) carrier status on age-at-diagnosis of Alzheimer disease (AD) in APOE4 carriers.
Methods: Patients aged 50-74 years with cerebrospinal fluid (CSF) biomarker-confirmed AD, were recruited to clinical trial (NCT03186989 since June 14, 2017). Baseline demographics, disease characteristics, and biomarkers were evaluated in 45 patients according to BCHE-K and APOE4 allelic status in this post-hoc study.
Anthelmintic and Hepatoprotective Activities of the Green-Synthesized Zinc Oxide Nanoparticles Against Parascaris equorum Infection in Rats.
Acta Parasitol
March 2024
Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.
Main Conclusions: Green-synthesized zinc oxide nanoparticle is a promising treatment modality against parasitic infection through its powerful anthelmintic, antioxidant, healing promotion, and anti-inflammation effects.
Background: Nanoparticles have many properties, depending on their size, shape, and morphology, allowing them to interact with microorganisms, plants, and animals.
Objectives: Investigation of the therapeutic effects of green-synthesized zinc oxide nanoparticles (ZnO NPs) on Parascaris equorum infection in rats.
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