Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0304-4165(72)90111-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Alternating Aerobics with Resistance Exercise Improves Bone Density and Circulating Irisin Levels in Postmenopausal Women.
Med Sci Sports Exerc
December 2024
Shanghai University of Sport, Shanghai, CHINA.
Purpose: Irisin plays an important role in bone-muscle crosstalk. The aim of this study was to elucidate the association of long-term exercise induced irisin response with body composition and bone mineral density in postmenopausal women.
Methods: We recruited 29 postmenopausal women (age: 62.
Impact of Adding -hexylamine to Nickel Metallophotoredox C-N Coupling to Form Diarylamines.
J Org Chem
January 2025
School of Chemistry, State Key Laboratory of Fine Chemicals, Frontier Science Center for Smart Materials, Dalian Key Laboratory of Intelligent Chemistry, Dalian University of Technology, Dalian 116024, China.
The mechanistic understanding of how alkylamines impact Ni-metallophotoredox C-N coupling to form diarylamines remains unclear. In this study, 12-alkylamines were evaluated as additives to determine their effects on the synthesis of diarylamines in a flow photochemical system. Notably, -hexylamine demonstrated the most significant promotional effect.
View Article and Find Full Text PDFImproving the Reliability of Language Model-Predicted Structures as Docking Targets through Geometric Graph Learning.
J Med Chem
January 2025
Hangzhou Carbonsilicon AI Technology Company Limited, Hangzhou 310018, Zhejiang, China.
Applying artificial intelligence techniques to flexibly model the binding between the ligand and protein has attracted extensive interest in recent years, but their applicability remains improved. In this study, we have developed CarsiDock-Flex, a novel two-step flexible docking paradigm that generates binding poses directly from predicted structures. CarsiDock-Flex consists of an equivariant deep learning-based model termed CarsiInduce to refine ESMFold-predicted protein pockets with the induction of specific ligands and our existing CarsiDock algorithm to redock the ligand into the induced binding pockets.
View Article and Find Full Text PDFFast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.
PLoS Comput Biol
January 2025
Department of Mechanical Engineering & Materials Science, Washington University, St. Louis, Missouri, United States of America.
Cell collectives, like other motile entities, generate and use forces to move forward. Here, we ask whether environmental configurations alter this proportional force-speed relationship, since aligned extracellular matrix fibers are known to cause directed migration. We show that aligned fibers serve as active conduits for spatial propagation of cellular mechanotransduction through matrix exoskeleton, leading to efficient directed collective cell migration.
View Article and Find Full Text PDFA signaling molecule from intratumor bacteria promotes trastuzumab resistance in breast cancer cells.
Proc Natl Acad Sci U S A
January 2025
Key Laboratory of Molecular Nanostructure and Nanotechnology, Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Emerging evidence indicates that intratumor bacteria exist as an active and specific tumor component in many tumor types beyond digestive and respiratory tumors. However, the biological impact and responsible molecules of such local bacteria-tumor direct interaction on cancer therapeutic response remain poorly understood. Trastuzumab is among the most commonly used drugs targeting the receptor tyrosine-protein kinase erbB-2 (ErbB2) in breast cancer, but its resistance is inevitable, severely limiting its clinical effectiveness.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!