In dogs with experimental myocardial infarction the anterior descending branch of the left coronary artery was ligated and 1, 2, 3, 5, and 10 days later its circumflex branch was catheterized and perfused, and coronary circulation in the intact myocardial zone, systemic hemodynamics, the AMP content and the activity of enzymes catalysing adenosine metabolism were studied. In the intact myocardial zone resistance increases in the coronary vessels and neurohumoral regulation is disturbed, the beta-adrenergic and cholinergic reactions of dilation are weakened, alpha-adrenergic pressor effect of catecholamines on the cardiac vessels is manifested, and adenosine metabolism is disturbed. Disorders of adenosine metabolism are regarded among the possible mechanisms of coronary circulatory disorders in the intact zone of the myocardium.
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