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Quercetin Supplementation Reduces Oxidative Stress in the Testes of Wistar Rats Fed a High-Fat Diet.
Am J Reprod Immunol
January 2025
Laboratory of Molecular Genetics and Experimentation in Animal Reproduction, University of Western São Paulo (Unoeste), Presidente Prudente, São Paulo, Brazil.
Problem: A high-fat diet (HFD) predisposes animals to glucose intolerance, dyslipidemia and testicular oxidative stress, and impairs sperm production in rats. Quercetin is a flavonoid with antioxidant, anti-inflammatory, and lipolytic actions and is a potential supplement to combat the oxidative stress caused by HFD and its harmful effects on reproduction. This study evaluated the effects of quercetin supplementation at doses of 10 and 20 mg/day on reproductive parameters and testicular oxidative stress in Wistar rats fed a diet rich in pork fat and fructose.
View Article and Find Full Text PDFTranscriptional regulation of adipocyte lipolysis by IRF2BP2.
Sci Adv
January 2025
Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Article Synopsis
- Adipocyte lipolysis plays a crucial role in regulating overall energy levels and metabolic balance, primarily controlled by specific enzymes and their modifications.
- The study identifies IRF2BP2 as a transcriptional repressor that, when deleted, boosts lipolysis in human adipocytes without altering glucose uptake, while its overexpression has the opposite effect.
- The research further reveals that the deletion of IRF2BP2 in mice leads to increased lipolysis and inflammation in adipose tissue, suggesting potential strategies for targeting lipolysis in metabolic disease treatments.
Nesfatin-1 as a crucial mediator of glucose homeostasis in the reptile, Hemidactylus flaviviridis.
Sci Rep
December 2024
University of Jammu, Jammu and Kashmir, 180006, India.
Nesfatin-1 is a crucial regulator of energy homeostasis in mammals and fishes, however, its metabolic role remains completely unexplored in amphibians, reptiles, and birds. Therefore, present study elucidates role of nesfatin-1 in glucose homeostasis in wall lizard wherein fasting stimulated hepatic nucb2/nesfatin-1, glycogen phosphorylase (glyp), phosphoenolpyruvate carboxykinase (pepck), and fructose 1,6-bisphosphatase (fbp), while feeding upregulated pancreatic nucb2/nesfatin-1 and insulin, suggesting towards tissue-specific dual role of nesfatin-1 in glucoregulation. The glycogenolytic/gluconeogenic role of nesfatin-1 was further confirmed by an increase in media glucose levels along with heightened hepatic pepck and fbp expression and concomitant decline in liver glycogen content in nesfatin-1-treated liver of wall lizard.
View Article and Find Full Text PDFAmeliorative effect of phenolic compound-pterostilbene on corticosterone-induced hepatic lipid metabolic disorder in broilers.
J Nutr Biochem
December 2024
College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. Electronic address:
The aim of this study was to investigate the ameliorative effects of pterostilbene (PTE), a polyphenolic compound, on stress-induced lipid metabolic disorders in the liver of broiler chickens. Six hundred healthy, 1-day-old Arbor Acres with similar weight were randomly assigned to five groups, each consisting of eight replicates with 15 broilers per replicate. The groups included: a control group (fed a basal diet), and four groups treated with corticosterone (CORT) at varying dietary levels of PTE supplementation: CORT (0 mg/kg PTE), CORT-PT200 (200 mg/kg PTE), CORT-PT400 (400 mg/kg PTE), and CORT-PT600 (600 mg/kg PTE).
View Article and Find Full Text PDFBiodegradation of various edible oils and fat by Staphylococcus petrasii sub sp. jettensis VSJK R1 for application in bioremediation of lipid rich restaurant wastewater.
Braz J Microbiol
December 2024
Laboratory of Photobiology and Molecular Microbiology, Department of Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India.
Article Synopsis
- - The study isolated a new bacterial strain, Staphylococcus petrasii sub sp. jettensis (VSJK R1), which efficiently degrades fats, oils, and grease (FOG) pollutants commonly found in wastewater from sources like restaurants and kitchens.
- - Optimal biodegradation conditions were identified, including the use of organic nitrogen sources, glucose, neutral pH, and specific temperature ranges (22°C to 45°C), leading to significantly improved degradation rates.
- - Comparisons to other microbial strains highlighted the exceptional ability of VSJK R1 to break down various edible oils, suggesting its potential for bioremediation in wastewater treatment facilities and grease traps.
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