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9-PAHSA ameliorates microvascular damage during cardiac ischaemia/reperfusion injury by promoting LKB1/AMPK/ULK1-mediated autophagy-dependent STING degradation.
Phytomedicine
January 2025
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address:
Background: Considering that cardiac microvascular injury may play a more critical role than cardiomyocyte injury in the pathology of early ischaemia/reperfusion (I/R) injury, therapeutic strategies targeting the microvasculature are highly desirable. Palmitic acid-9-hydroxystearic acid (9-PAHSA) is a new class of bioactive anti-inflammatory lipids widely distributed in vegetables, fruits and medicinal plants, especially broccoli and apple. However, the pharmacological effects and underlying mechanisms of 9-PAHSA in protecting- against cardiac microvascular I/R injury have rarely been studied.
View Article and Find Full Text PDFReducing the prime cardiopulmonary bypass volume during paediatric cardiac surgery.
Perfusion
November 2024
Department of Cardiovascular Anesthesia and Critical Care, CHU Bordeaux, Bordeaux, France.
Introduction: Despite technological advances, the use of homologous blood to prime the cardiopulmonary bypass (CPB) circuits of infants under 10 kg remains common. However, such rapid massive transfusion may increase post-CPB morbidity.
Method: We retrospectively included consecutive patients weighing 2.
Allogenic Vertebral Body Adherent Mesenchymal Stromal Cells Promote Muscle Recovery in Diabetic Mouse Model of Limb Ischemia.
Ann Vasc Surg
January 2025
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Article Synopsis
- * In the experiment, diabetic mice underwent surgery to induce CLTI, followed by vBA-MSC injections into the affected muscle, which resulted in improved limb perfusion, muscle recovery, and reduced fibrosis when compared to control mice.
- * Results showed significant upregulation of key genes associated with muscle regeneration and angiogenesis, suggesting that vBA-MSC therapy offers a promising approach to enhance recovery in ischemic muscle conditions.
Iron changes within infarct tissue in ischemic stroke patients after successful reperfusion quantified using QSM.
Neuroradiology
December 2024
Department of Radiology, The University of Melbourne, Parkville, VIC, 3050, Australia.
Purpose: For nearly half of patients who undergo Endovascular Thrombectomy following ischemic stroke, successful recanalisation does not guarantee a good outcome. Understanding the underlying tissue changes in the infarct tissue with the help of biomarkers specific to ischemic stroke could offer valuable insights for better treatment and patient management decisions. Using quantitative susceptibility mapping (QSM) MRI to measure cerebral iron concentration, this study aims to track the progression of iron within the infarct lesion after successful reperfusion.
View Article and Find Full Text PDFEnhancing the biological integration of massive bone allografts: A porcine preclinical in vivo pilot-study.
Bone
October 2024
Institut de Recherche Expérimentale et Clinique, Neuro Musculo-Skeletal Lab, Université Catholique de Louvain, Avenue E. Mounier, 52-B1.52.04 - 1200, Bruxelles, Belgium; Service de Chirurgie Orthopédique et Traumatologique, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10-1200, Bruxelles, Belgium; Unité de Thérapie Tissulaire et Cellulaire de l'Appareil Locomoteur, Cliniques Universitaires Saint-Luc, Avenue Hippocrate 10-1200, Bruxelles, Belgium.
Critical bone loss can have several origins: infections, tumors or trauma. Therefore, massive bone allograft can be a solution for limb salvage. Such a biological reconstruction should have the ideal biomechanical qualities.
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