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Genome-Wide Characterization of Extrachromosomal Circular DNA in the Midgut of BmCPV-Infected Silkworms and Its Potential Role in Antiviral Responses.
Int J Mol Sci
January 2025
School of Life Sciences, Soochow University, Suzhou 215123, China.
Extrachromosomal circular DNAs (eccDNAs) has been found to be widespread and functional in various organisms. However, comparative analyses of pre- and post-infection of virus are rarely known. Herein, we investigated the changes in expression patterns of eccDNA following infection with cytoplasmic polyhedrosis virus (BmCPV) and explore the role of eccDNA in viral infection.
View Article and Find Full Text PDFBaculovirus protein kinase 1 activates AMPK-protein phosphatase 5 axis to hijack transcription factor EB for self-proliferation.
Int J Biol Macromol
January 2025
Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; Guangdong Sericulture Engineering Research Center, College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:
Baculovirus causes lethal nuclear polyhedrosis in insects, whereas its regulatory mechanism on host transcription has not been fully illustrated. Herein, Bombyx mori nucleopolyhedrovirus (BmNPV) infection caused dephosphorylation and thus cytoplasmic-nucleo translocation of transcription factor EB (BmTFEB) by inhibiting Mechanistic target of rapamycin complex 1 (MTORC1), while upregulating Adenosine monophosphate-activated protein kinase (AMPK) signaling to promote self-proliferation through the rival protein kinase 1 in Bombyx mori. Significantly, B.
View Article and Find Full Text PDFA gene-encoded bioprotein second harmonic generation (SHG) probe from Autographa californica nuclear polyhedrosis virus (AcMNPV) polyhedrin for live cell imaging.
Eur Biophys J
January 2025
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
Compared to fluorescence, second harmonic generation (SHG) has recently emerged as an excellent signal for imaging probes due to its unmatched advantages in terms of no photobleaching, no phototoxicity, no signal saturation, as well as the superior imaging accuracy with excellent avoidance of background noise. Existing SHG probes are constructed from heavy metals and are cellular exogenous, presenting with high cytotoxicity, difficult cellular uptake, and the limitation of non-heritability. We, therefore, initially propose an innovative gene-encoded bioprotein SHG probe derived from Autographa californica nuclear polyhedrosis virus (AcMNPV) polyhedrin.
View Article and Find Full Text PDF() Is Involved in Host Protection Against Viral Infection.
Int J Mol Sci
December 2024
Guangxi Key Laboratory of Sericultural Genetic Improvement and Efficient Breeding, Sericulture Technology Promotion Station of Guangxi, Nanning 530007, China.
Baculoviruses, the largest studied insect viruses, are highly pathogenic to host insects. nucleopolyhedrovirus (BmNPV) is the main cause of nuclear polyhedrosis of silkworm, a viral disease that causes significant economic losses to the sericulture industry. The anti-BmNPV mechanism of the silkworm has not yet been characterized.
View Article and Find Full Text PDFSingle-nucleus RNA sequencing reveals midgut cellular heterogeneity and transcriptional profiles in Bombyx mori cytoplasmic polyhedrosis virus infection.
Insect Sci
November 2024
Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou, China.
Article Synopsis
- The gut in insects like silkworms is crucial for digestion and also acts as a barrier against harmful pathogens, but there's limited understanding of how their immune system responds to viral infections.
- This study utilized single-nucleus RNA sequencing to explore different cell types in the silkworm midgut and examined how the Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) affects these cells.
- Findings suggest that BmCPV not only decreases antiviral responses but also increases the expression of genes promoting viral replication, indicating a complex interplay between the virus and the host's immune system.
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