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Optogenetic Modulation of Intraocular Pressure in a Glucocorticoid-Induced Ocular Hypertension Mouse Model.
Transl Vis Sci Technol
May 2021
Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA, USA.
Purpose: Steroid-induced glaucoma is a common form of secondary open angle glaucoma characterized by ocular hypertension (elevated intraocular pressure [IOP]) in response to prolonged glucocorticoid exposure. Elevated IOP occurs with increased outflow resistance and altered trabecular meshwork (TM) function. Recently, we used an optogenetic approach in TM to regulate the 5-phosphatase, OCRL, which contributes to regulating PI(4,5)P2 levels.
View Article and Find Full Text PDFEpibulbar osseous choristoma: A clinical case and review of the literature.
Arch Soc Esp Oftalmol (Engl Ed)
June 2020
Instituto Nacional de Oftalmología Dr. Francisco Contreras Campos, Lima, Perú; Laboratorio de Patología Ocular Dr. José Antonio Avendaño Valdez, Instituto Nacional de Oftalmología Dr. Francisco Contreras Campos, Lima, Perú.
We present the case of a 3-year-old male child with an epibulbar bone choristoma. The patient presented with a hard consistency subconjunctival mass of 8×10mm in the superior-temporal quadrant of his right eye along with vascularisation and a long cilium of approximately 8 to 10mm that touched the corneal surface. The histopathology study showed the presence of trabeculae of mature, compact bone surrounded by fibrous tissue, as well as Havers channels with concentric rings of laminar bone without bone marrow, and with normal osteocytes which defined the diagnosis of epibulbar bone choristoma.
View Article and Find Full Text PDFArticle Synopsis
- - A 7-year-old female snow leopard had severe eye issues including an ulcer in the right cornea that did not improve with 5 weeks of medical treatment.
- - Surgical treatments included grafting with equine amniotic membrane and eyelid revision, which were necessary after initial medical management failed.
- - The grafts successfully healed the eye conditions, preserving the globe and restoring vision, suggesting this technique is viable for eye repairs in wild animals with limited post-op care options.
The role of entrapped cilia on the formation of lacrimal ductular cysts.
Jpn J Ophthalmol
March 2015
Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, Korea.
Purpose: We sought to describe the histopathologic features of lacrimal ductular cysts with or without inflammation and speculate on the role of cilia in their pathogenesis.
Materials And Methods: A retrospective study of 15 patients referred for lateral canthal subconjunctival cysts from 2001 to 2012 was conducted. All patients underwent cyst removal and a total histopathological examination was done.
Clinicopathological features of inflammatory lesions of the lateral canthal subconjunctival area.
Ophthalmic Plast Reconstr Surg
October 2014
*Department of Ophthalmology, Seoul National University College of Medicine; †Department of Pathology, Seoul National University Boramae Hospital, Seoul; ‡Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam; §Department of Ophthalmology, Seoul National University Boramae Hospital; ‖Department of Ophthalmology, Seoul National University Hospital, Seoul; and ¶Department of Ophthalmology, Hallym University Sacred Heart Hospital, Anyang, Korea.
Purpose: To investigate the clinical and histopathological features of inflammatory lesions of the lateral canthal subconjunctival area.
Methods: This is a retrospective case series of 12 patients with inflammatory subconjunctival masses in the lateral canthal area. All patients included in this study were treated at Seoul National University Hospital or Seoul National University Bundang Hospital between 2006 and 2012.
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