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Methylmercury-induced visual deficits involve loss of GABAergic cells in the zebrafish embryo retina.
Sci Total Environ
January 2025
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, 100012 Beijing, China. Electronic address:
Methylmercury (MeHg) is a neurotoxicant with adverse effects on visual systems from fish to man. Clinical signs of visual deficits including color-vision alterations, visual field constriction and blindness have been frequently identified in patients and affected animals following acute and chronic exposure to MeHg. However, it is still unclear whether MeHg causes developmental defects in the eye.
View Article and Find Full Text PDFSeafood Toxicant Exposure During Pregnancy, Lactation, and Childhood and Child Outcomes: A Scoping Review.
Adv Nutr
December 2024
Division of AgriLife Research, Texas A&M Agriculture, Food and Nutrition Evidence Center, AgriLife Research, Fort Worth, TX, United States; Department of Nutrition, Texas A&M University, College Station, Texas, United States.
Determining dietary recommendations for seafood consumed during pregnancy, lactation, and childhood requires consideration of the known nutritional benefits and potential harm due to toxicant exposure as they relate to child outcomes. This study aimed to describe the scope of the evidence associated with seafood-related toxicant exposure and child outcomes and to identify toxicant-outcome pairs that may have sufficient evidence to conduct a systematic review. We included studies examining seafood toxicant exposure during pregnancy, lactation, and childhood, and child outcomes.
View Article and Find Full Text PDFThe emerging application of LC-based metallomics techniques to unravel the bioinorganic chemistry of toxic metal(loid)s.
J Chromatogr A
November 2024
Department of Chemistry, University of Calgary, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada. Electronic address:
The on-going anthropogenic emission of toxic metal(loid) species into the environment contaminates the food supply and drinking water resources in various parts of the world. Given that inorganic pollutants cannot be degraded, their increased influx into the bloodstream of babies, children and pregnant women is inevitable. Since the ramifications of the ensuing environmental exposure on human health remain poorly defined, fundamentally new insight into their bioinorganic chemistry in organisms is urgently needed.
View Article and Find Full Text PDFMercury-induced toxicity: Mechanisms, molecular pathways, and gene regulation.
Sci Total Environ
September 2024
State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, 100012 Beijing, China. Electronic address:
Mercury is a well-known neurotoxicant for humans and wildlife. The epidemic of mercury poisoning in Japan has clearly demonstrated that chronic exposure to methylmercury (MeHg) results in serious neurological damage to the cerebral and cerebellar cortex, leading to the dysfunction of the central nervous system (CNS), especially in infants exposed to MeHg in utero. The occurrences of poisoning have caused a wide public concern regarding the health risk emanating from MeHg exposure; particularly those eating large amounts of fish may experience the low-level and long-term exposure.
View Article and Find Full Text PDFGabapentin improves neuropathic pain in Minamata disease model rats.
Environ Health Prev Med
June 2024
Department of Basic Medical Sciences, National Institute for Minamata Disease.
Article Synopsis
- Methylmercury (MeHg) causes significant damage to the nervous system, leading to symptoms like sensory disturbances and neuropathic pain in chronic Minamata disease patients.
- Gabapentin was tested on Minamata disease model rats to see if it could alleviate neuropathic pain, with analyses conducted on the nervous system to understand its effects.
- The study found that while gabapentin did not reverse neurodegeneration or microglial activation, it appeared to reduce synaptic rewiring in the somatosensory cortex, suggesting it may help manage neuropathic pain related to MeHg poisoning.
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