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Article Synopsis
  • The study investigates the effects of menstrual cycle phases and time of day on various stress and immune biomarkers, including salivary α-amylase (sAA) and secretory immunoglobulin A (SIgA), in a group of 17 participants.
  • No significant interactions were found between menstrual cycle phases and time of day for the biomarkers, resting blood pressure, heart rate, or body composition.
  • However, results indicate that resting heart rate and sAA levels were higher in the afternoon, while SIgA levels were higher in the morning, highlighting the influence of time of day on these markers, rather than the menstrual cycle phases.
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Understanding human endometrial dynamics in the establishment of endometrial receptivity remains a challenge, which limits early diagnosis and treatment of endometrial-factor infertility. Here, we decode the endometrial dynamics of fertile women across the window of implantation and characterize the endometrial deficiency in women with recurrent implantation failure. A computational model capable of both temporal prediction and pattern discovery is used to analyze single-cell transcriptomic data from over 220,000 endometrial cells.

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This study aimed to evaluate the ovulatory response to GnRH treatment based on the day of its administration in the first follicular wave of the estrous cycle in goats. We hypothesized that maximum ovulatory response with GnRH treatment is dependent on the day of its administration during the early luteal phase of estrous cycle. Forty-eight goats were presynchronized with a single dose of PGF, and ultrasonography was performed to confirm ovulation (Day 0).

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Perinatal outcomes of progesterone in natural frozen-thawed embryo transfer pregnancies: insights from two randomized controlled trials.

Fertil Steril

December 2024

Department of Women's and Children's Health, Uppsala University, 751 85 Uppsala, Sweden; Reproduction Center, Uppsala University Hospital, 751 85 Uppsala, Sweden; Division of Obstetrics and Gynaecology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 171 77 Stockholm, Sweden.

Objective: To explore whether progesterone supplementation during luteal phase and early pregnancy following a natural frozen-thawed embryo transfer cycle (NC-FET) affects perinatal outcomes.

Design: A secondary data analysis study based on two randomized control trials taking place during 2008-2011 and 2013-2018 at two university hospitals in Sweden.

Subjects: A total of 923 women undergoing a natural FET cycle.

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Purpose: To elucidate if morning or evening start of exogenous progesterone (P4) five days before blastocyst embryo transfer (ET) impacts ongoing pregnancy rates (OPR) in artificial cycles.

Methods: Single-centre retrospective cohort study of 6493 artificial cycles for an ET (oestrogens and luteal phase support [LPS] with micronized vaginal progesterone [MVP] 400 mg/12 h), conducted at an infertility clinic, December 2018-July 2022. LPS was given from five days before ET.

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