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Mitochondrial quality control: Biochemical mechanism of cardiovascular disease.
Biochim Biophys Acta Mol Cell Res
January 2025
Department of Veterinary Sciences, University of Messina, 98168 Messina, Italy. Electronic address:
Mitochondria play a key role in the regulation of energy homeostasis and ATP production in cardiac cells. Mitochondrial dysfunction can trigger several pathological events that contribute to the development and progression of cardiovascular diseases. These mechanisms include the induction of oxidative stress, dysregulation of intracellular calcium cycling, activation of the apoptotic pathway, and alteration of lipid metabolism.
View Article and Find Full Text PDFCase Report: Efficacy and safety of recombinant growth hormone therapy in a girl with Loeys-Dietz syndrome.
Front Cardiovasc Med
January 2025
Department of Pediatric Endocrinology and Rheumatology, Institute of Pediatrics, Poznan University of Medical Sciences, Poznan, Poland.
Background: Loeys-Dietz syndrome (LDS) is a clinically and genetically heterogeneous, autosomal dominant aortic aneurysm syndrome with widespread systemic involvement. We present the case of a 16.5-year-old girl with LDS type 2 (LDS2) caused by a heterozygous pathogenic variant, c.
View Article and Find Full Text PDFAnti-Ulcerogenic Activity of the Marine-Pearl Derived Medicine Mukta Pishti in Rat Model of Pylorus Ligation-Induced Peptic Ulcer.
J Ethnopharmacol
January 2025
Drug Discovery and Development Division, Patanjali Research Foundation, Haridwar 249 405, Uttarakhand, India; Special Centre for Systems Medicine, Jawaharlal Nehru University, New Delhi 110 067, India. Electronic address:
Ethnopharmacological Relevance: Mukta Pishti (MKP) is a traditional Ayurvedic medicine described in classical textbook 'Rasatarangini' and synthesized from marine pearls following classical methodology. MKP is used as therapeutic medicine against hyperacidity, irritable bowel syndrome, and gastric ulcers.
Aim Of The Study: Here, we explored the therapeutic properties of MKP in alleviating peptic ulcer in Male Wistar rat model of pylorus ligation.
Decoding the MMP14 Integrin Link: Key Player in the Secretome Landscape.
Matrix Biol
January 2025
Institute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany. Electronic address:
Rapid progress has been made in the exciting field of secretome research in health and disease. The tumor secretome, which is a significant proportion of the tumor proteome, is secreted into the extracellular space to promote intercellular communication and thus tumor progression. Among the many molecules of the secretome, integrins and matrix metalloproteinase 14 (MMP14) stand out as the interplay of adhesion and proteolysis drives invasion.
View Article and Find Full Text PDFAdolescent primary hyperparathyroidism.
Best Pract Res Clin Endocrinol Metab
January 2025
Department of Endocrinology, Seth G.S. Medical College and King Edward Memorial Hospital, Mumbai, India. Electronic address:
Adolescent primary hyperparathyroidism (PHPT) is a rare endocrine disorder bearing distinctions from the adult form. This review examines its unique aspects, focusing on clinical presentation, genetic etiologies, genotype-phenotype correlations, and therapeutic management. Adolescent PHPT often has a genetic basis, whether familial, syndromic, or apparently sporadic, and identifying the underlying genetic cause is important for patient care.
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