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The test for somatic mutagenesis and recombination in Drosophila is one of the widely used approaches for determination of possible carcinogenic effects of chemical compounds. The use of heterozygotes for mutant tumor suppressor gene wts enables more direct evaluation of the blastomogenic effects of chemical compounds, by tumor formation in the adult flies. This study presents evaluation of the SMART effectiveness upon the use of Drosophila heterozygotes for the wts(P4) gene, first included into the test system.
View Article and Find Full Text PDFA basically new system has been developed to screen carcinogens in Drosophilidae, which is based on somatic mutagenesis and recombination. The system may induce tumors in Drosophilidae, which are recorded in adult insects. The test uses recessive mutation in the suppressor gene of growth of warts (wts) tumors.
View Article and Find Full Text PDFCatecholestrogens excretion in smoking and non-smoking postmenopausal women receiving estrogen replacement therapy.
J Steroid Biochem Mol Biol
March 2000
Laboratory Oncoendocrinology, Prof. N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia.
Estrogens are involved in the etiology of breast cancer. Their blastomogenic influence may be partly realized through their conversion into catecholestrogens, rate of which may be modified by smoking. The risk of having breast cancer diagnosed can increase in women using estrogen replacement therapy (ERT).
View Article and Find Full Text PDFIt is proved in experiments with the interrupting and twenty-four hour inhalations and peroral use of nitrosodimethylamine on the Wistar and white rats, that blastomogenic effect is submitted to the dose-effect dependence. On the whole the tumour incidence is determined by a total dose of carcinogen but its size may vary to a considerable extent depending on the regime of nitrosodimethylamine delivery. The daily and single doses of carcinogen are of great importance.
View Article and Find Full Text PDFThe possibility of regulating the permissible quantities of chemical carcinogens in the environment is being substantiated. The ways of determining the threshold amounts of blastomogenic agents are discussed. Some approaches to the regulation of blastomogens are suggested depending on the degree of risk, effective quantities and action time.
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