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Inflammatory Pathways of Sulfonamide Diuretics: Insights into SLC12A Cl Symporters and Additional Targets.
Cell Physiol Biochem
January 2025
Department of Pharmacology and Toxicology, Wright State University, School of Medicine. Dayton, Ohio, United States,
Thiazide, thiazide-like, and loop diuretics are primarily known for inhibiting members of the SLC12A family of Cl transporters, which include the Na+Cl cotransporter (NCC), NaK2Cl cotransporters (NKCC1 and NKCC2) and KCl symporters (KCC1-4). While the main pharmacological effect of these diuretics is diuresis, achieved by promoting the excretion of excess water and salt through the kidneys, they have intriguing pharmacological effects beyond their traditional ones which cannot be solely attributed to their effects on renal salt transport. Of particular interest is their role in modulating inflammatory processes.
View Article and Find Full Text PDFOptimization of adsorption performance by mesoporous materials developed from local clays and zeolite. Application in the treatment of real pharmaceutical effluents.
J Environ Sci Health B
January 2025
Laboratoire Génie Civil et d'Hydraulique, Université 8 Mai 1945, Guelma, Algeria.
The treatment of effluents from the pharmaceutical industry currently remains a major challenge due to their impact on the environment and public health along with the cost of treatments. Considering these issues, our work focused on the development of materials with effective adsorption properties to treat industrial effluents based on locally available and inexpensive clays and zeolite. Local Algerian kaolin (Djebel Debbagh), palygorskite (Ghoufi) and zeolite (Tinbdar) were treated thermally and chemically prior to synthesis into mesoporous materials of hexagonal structure using pluronic P123 as surfactant.
View Article and Find Full Text PDFIcodextrin versus Glucose 2.5% on markers of hypervolemia and survival of patients undergoing automated peritoneal dialysis with an unplanned start: a randomized controlled trial.
Einstein (Sao Paulo)
December 2024
Internal Medicine Department, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, Botucatu, SP, Brazil.
Objective: The efficacy of icodextrin versus glucose patients undergoing peritoneal dialysis remains unclear. The study was designed to compare the effects of once-daily long-dwell icodextrin versus glucose on markers of hypervolemia and survival among patients with kidney failure undergoing an unplanned initiation of automated peritoneal dialysis.
Methods: This was a randomized, non-blinded, and prospective controlled study.
Corticotropin-releasing factor-like diuretic hormone 44 and five corresponding GPCRs in Drosophila suzukii: Structural and functional characterization.
J Insect Physiol
December 2024
USDA-ARS, Horticultural Crops Disease and Pest Management Research Unit, USA. Electronic address:
Diuretic hormones (DHs) activate corresponding G protein-coupled receptors (GPCRs), mediating the water and ion homeostasis in arthropods. There are two different DHs known to be expressed in insects, calcitonin (CT)-like DH31 and corticotropin-releasing factor (CRF)-like DH44. In this study, we identified and characterized a DH44 and five GPCR variants, DH44-R1 and DH44-R2a/b/c/d, in Drosophila suzukii (spotted-wing drosophila), causing detrimental damage to fresh and soft-skinned fruits.
View Article and Find Full Text PDFRole of intermittent hypoxic training combined with methazolamide in the prevention of high-altitude cerebral edema in rats.
Sci Rep
December 2024
Department of Neurosurgery, Neuromedicine Center, Beijing Shijitan Hospital, Capital Medical University, No. 10, Tieyi Road, Yangfangdian, Haidian District, Beijing, 100038, China.
Article Synopsis
- Intermittent hypoxia training (IHT) and methazolamide (MTZ) show limited effectiveness individually in preventing high-altitude cerebral edema (HACE), with few studies exploring their combined use.
- A rat model was developed to study the effects of IHT and MTZ on behavior, brain water content, pathology, and protein expression after exposure to hypobaric hypoxia and exhaustive exercise.
- The combination of long-course IHT and MTZ demonstrated the most significant improvement in spatial and memory function, brain pathology, and protein levels, indicating a potential effective approach for preventing HACE.
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