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Voltage-sensitive calcium channels contribute to depolarization of both motor neurons and interneurons in animal studies, but less is known of their contribution to human motor control and whether blocking them has potential in future antispasmodic treatment in humans. Therefore, this study investigated the acute effect of nimodipine on the transmission of human spinal reflex pathways involved in spasticity. In a double-blinded, crossover study, we measured soleus muscle stretch reflexes and H reflexes and tibialis anterior cutaneous reflexes in 19 healthy subjects before and after nimodipine (tablet 60 mg) or baclofen (tablet 25 mg).
View Article and Find Full Text PDFRate-Dependent Depression of the Hoffmann Reflex: Practical Applications in Painful Diabetic Neuropathy.
Diabetes Metab J
November 2024
Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Article Synopsis
- The rate-dependent depression (RDD) of the Hoffmann (H) reflex is a technique used to measure the integrity of spinal reflex pathways and has been valuable for understanding movement disorders like spasticity following spinal cord injuries.
- Recent interest has emerged in using RDD as a biomarker for spinal disinhibition, a process that can worsen certain pain conditions, emphasizing its potential for targeted pain therapy.
- Ongoing research, especially in diabetic subjects, is examining disorders related to spinal GABAergic function and aims to deepen the understanding and clinical applications of RDD in pain management.
Frequency-dependent effects of superimposed NMES on spinal excitability in upper and lower limb muscles.
Heliyon
November 2024
Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy.
Superimposing neuromuscular electrical stimulation (NMES) on voluntary contractions has proven to be highly effective for improving muscle strength and performance. These improvements might involve specific adaptations occurring at cortical and spinal level. The effects of NMES on corticospinal activation seem to be frequency dependent and differ between upper and lower limb muscles.
View Article and Find Full Text PDFIntermittent hypoxia enhances voluntary activation and reduces performance fatigability during repeated lower limb contractions.
J Neurophysiol
December 2024
Sensorimotor Recovery and Neuroplasticity Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado, United States.
Prior research has highlighted the therapeutic benefits of acute intermittent hypoxia (AIH) in enhancing motor performance after motor incomplete spinal cord injury and in able-bodied individuals. Although studies in rodents and humans indicate that AIH may facilitate motor excitability, the relationship between excitability changes and functional performance remains unclear. In addition, discrepancies in the effects of AIH on excitability in able-bodied individuals merit further investigation.
View Article and Find Full Text PDFEnhancing motor performance through brief skin cooling: exploring the role of enhanced sympathetic tone and muscle spindle sensitivity.
Eur J Appl Physiol
September 2024
İstanbul Physical Therapy Rehabilitation Training and Research Hospital, Adnan Kahveci Blv. No : 145, Bahçelievler, 34186, Istanbul, Turkey.
Background: Although brief skin cooling (BSC) is widely used in sports medicine and rehabilitation for its positive effects on motor performance, the mechanism underlying this motor facilitation effect remains unclear.
Objectives: To explore the hypothesis that BSC enhances muscle force generation, with cold-induced sympathetic activation leading to heightened muscle spindle sensitivity, thereby contributing to this effect.
Methods: The study involved two experiments.
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