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Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies.
Cell
November 2024
Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA. Electronic address:
Endo-β-N-acetylglucosaminidases (ENGases) that specifically hydrolyze the Asn297-linked glycan on immunoglobulin G (IgG) antibodies, the major molecular determinant of fragment crystallizable (Fc) γ receptor (FcγR) binding, are exceedingly rare. All previously characterized IgG-specific ENGases are multi-domain proteins secreted as an immune evasion strategy by Streptococcus pyogenes strains. Here, using in silico analysis and mass spectrometry techniques, we identified a family of single-domain ENGases secreted by pathogenic corynebacterial species that exhibit strict specificity for IgG antibodies.
View Article and Find Full Text PDFCutaneous diphtheria from 2018 to 2022: an observational, retrospective study of epidemiological, microbiological, clinical, and therapeutic characteristics in metropolitan France.
Emerg Microbes Infect
December 2024
Internal Medicine Department, HIA Sainte-Anne, Toulon, France.
The incidence of diphtheria has been rising over the past decade, particularly in its cutaneous form. A clinical review of the case series was therefore required. We reviewed the epidemiological, clinical, microbiological and therapeutic data of cutaneous diphtheria cases, in adult patients living in metropolitan France with a skin sample positive for corynebacteria of the complex between 2018 and 2022.
View Article and Find Full Text PDFPreliminary In Vitro Evaluation of Silver, Copper and Gold Nanoparticles as New Antimicrobials for Pathogens That Induce Bovine Locomotion Disorders.
Int J Mol Sci
August 2024
Department of Nanobiotechnology, Warsaw University of Life Sciences, 02-786 Warszawa, Poland.
Lameness is a crucial problem in dairy farming. It worsens the welfare of cattle, reduces the milk yield, and causes economic losses. The etiology of lameness is varied and the cattle's condition may be infectious or non-infectious.
View Article and Find Full Text PDFUsing 16s rRNA sequencing to characterize the microbiome of tropical cutaneous ulcer disease: insights into the microbial landscape and implications for diagnosis and treatment.
Microb Genom
May 2024
Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Article Synopsis
- * By analyzing 38 samples using advanced sequencing methods, researchers discovered a wide variety of bacteria present, with no single species being found in every sample.
- * The findings suggest that the causes of these ulcers are complex and multifactorial, highlighting the need for deeper research into the bacteria involved to improve diagnosis and treatment options in affected regions.
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