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Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturing. Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies. The neural circuits through which these emerging therapeutics modulate feeding behavior remain undefined, particularly in comparison to established peptide-based GLP1RAs.
View Article and Find Full Text PDFMetagenomic analysis of fungal assemblages at a regional scale in high-altitude temperate forest soils: alternative methods to determine diversity, composition and environmental drivers.
PeerJ
January 2025
Laboratorio de Interacciones Bióticas, Centro de Investigación en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, San Felipe Ixtacuixtla, Tlaxcala, Mexico.
Background: Understanding the diversity and distribution of fungal communities at a regional scale is important since fungi play a crucial role in ecosystem functioning. Our study used environmental metagenomics to determine fungal communities in mountainous forest soils in the central highlands of Mexico.
Methods: We used four different bioinformatic workflows to profile fungal assemblages, .
Coronary artery disease (CAD) and peripheral artery disease (PAD) are common and dangerous conditions that are both driven by atherosclerosis. Despite sharing many major risk factors, their disease pathophysiology is not fully understood. In this study, we aimed to better distinguish common vs.
View Article and Find Full Text PDFPertinence between Preoperative Renal Function and Composition of Renal Calculi in Elderly Patients: A Retrospective Analysis.
Arch Esp Urol
December 2024
Department of Laboratory Medicine, Wenzhou People's Hospital; The Third Affiliated Hospital of Shanghai University; The Wenzhou Third Clinical College of Wenzhou Medical University, 325000 Wenzhou, Zhejiang, China.
Background: Kidney stone disease poses a significant challenge in the geriatric population. Preoperative renal function has been speculated to influence the composition of renal calculi, and consequently, the management approach. We studied the correlation between preoperative renal function and the composition of renal calculi in elderly patients, which could have implications for optimizing therapeutic strategies.
View Article and Find Full Text PDFYttrium-Enriched Phosphate Glass-Ceramic Microspheres for Bone Cancer Radiotherapy Treatment.
ACS Omega
December 2024
Advanced Materials Research Group, Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K.
This study presents the development and characterization of high yttrium-content phosphate-based glass-ceramic microspheres for potential applications in bone cancer radiotherapy treatment. The microspheres produced via flame spheroidization, followed by sieving, revealed a lack of aggregation and a narrow size distribution (45-125 μm) achieved across different yttrium oxide to glass ratio samples. Energy dispersive X-ray (EDX) analysis showed a significant increase in yttrium content within the microspheres with increasing yttrium oxide to glass ratio samples, ranging from approximately 1-39 mol % for 10Y-50Y microspheres, respectively.
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