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A Novel Peptide Mapping Method Utilizing Cysteine as a Reducing Agent.
Pharm Res
January 2025
Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.
Purposes: In the peptide mapping reduction process for monoclonal antibodies (mAbs) and other proteins, the conventional reducing reagents β-mercaptoethanol (β-ME) and dithiothreitol (DTT) pose challenges due to their strong odor and toxicity at high concentrations. Cysteine (Cys), an essential amino acid for new protein synthesis, is an overlooked, nontoxic, and odorless reducing agent. This study presents a novel peptide mapping method using Cys as the reducing agent.
View Article and Find Full Text PDFWound Segmentation with U-Net Using a Dual Attention Mechanism and Transfer Learning.
J Imaging Inform Med
January 2025
Computer Science Department, University of Geneva, Geneva, Switzerland.
Accurate wound segmentation is crucial for the precise diagnosis and treatment of various skin conditions through image analysis. In this paper, we introduce a novel dual attention U-Net model designed for precise wound segmentation. Our proposed architecture integrates two widely used deep learning models, VGG16 and U-Net, incorporating dual attention mechanisms to focus on relevant regions within the wound area.
View Article and Find Full Text PDFComparison of outcomes with and without intrastent placement during PMS surgery.
Sci Rep
January 2025
Department of Ophthalmology and Visual Science, Kochi Medical School, Kochi University, Kohasu, Oko-cho, Nankoku City, 783-8505, Kochi, Japan.
To assess the efficacy of using a nylon suture as a stent in the PreserFlo MicroShunt (PMS) lumen to prevent postoperative hypotony, 59 eyes that underwent PMS implantation with follow-up for > 6 months were analyzed. Patients were divided into no intrastenting (NST) and intrastenting (ST) groups, with the ST group subdivided into 9 - 0 nylon suture fully placed (9 F), 9 - 0 nylon suture placement in only half of the lumen (9 H), 10 - 0 nylon suture fully placed (10 F), and 10 - 0 nylon suture placement in only half of the lumen (10 H). The distribution was as follows: 23 eyes in the NST group, 10 in the 9 F group, 9 in the 9 H group, 11 in the 10 F group, and 6 in the 10 H group.
View Article and Find Full Text PDFAn exploration of RSM, ANN, and ANFIS models for methylene blue dye adsorption using Oryza sativa straw biomass: a comparative approach.
Sci Rep
January 2025
Amity Institute of Environmental Sciences (AIES), Amity University Uttar Pradesh (AUUP), Sector-125, Gautam Budh Nagar, Noida, 201313, India.
This study focused on simulating the adsorption-based separation of Methylene Blue (MB) dye utilising Oryza sativa straw biomass (OSSB). Three distinct modelling approaches were employed: artificial neural networks (ANN), adaptive neuro-fuzzy inference systems (ANFIS), and response surface methodology (RSM). To evaluate the adsorbent's potential, assessments were conducted using Fourier-transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM).
View Article and Find Full Text PDF[A preliminary study of risk factors for the stress fracture in treated with clavicle hook plate].
Zhongguo Gu Shang
January 2025
Ningbo Beilun People's Hospital, Ningbo 315800, Zhejiang, China.
Objective: To investigate the effects of bone density, plate bending degree and proximal screw type on the stress fracture of clavicle hook.
Methods: Three sows weighing between 45 and 50 kg were selected, from which a total of 40 rivs were collected. The 15 ribs of sows were divided into 3 groups according to bone density and bone hardness with 5 rivs in each group.
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