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Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction.
Front Immunol
January 2025
Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, China.
Background: Adenocarcinoma of the esophagogastric junction (AEGJ) is a highly aggressive tumor that frequently metastasizes to the liver. Understanding the cellular and molecular mechanisms that drive this process is essential for developing effective therapies.
Methods: We employed single-cell RNA sequencing to analyze the tumor heterogeneity and microenvironmental landscape in patients with AEGJ liver metastases.
Fundamentals of bio-based technologies for selective metal recovery from bio-leachates and liquid waste streams.
Front Bioeng Biotechnol
January 2025
Department of Agrobiotechnology, IFA-Tulln, Institute of Environmental Biotechnology, BOKU University of Natural Resources and Life Sciences Vienna, Tulln an der Donau, Austria.
The number of metal-containing waste streams resulting from electronic end-of life products, metallurgical by-products, and mine tailings to name but a few, is increasing worldwide. In recent decades, the potential to exploit these waste streams as valuable secondary resources to meet the high demand of critical and economically important raw materials has become more prominent. In this review, fundamental principles of bio-based metal recovery technologies are discussed focusing on microbial metabolism-dependent and metabolism-independent mechanisms as sustainable alternatives to conventional chemical metal recovery methods.
View Article and Find Full Text PDFDepressive symptoms and quality of life among women experiencing infertility: The moderating effect of perceived social support.
Heliyon
January 2025
School of Nursing, Research Institute of Nursing Science, Hallym University, Chuncheon, South Korea.
Background: Infertility constitutes a leading reproductive health problem with profound psychosocial outcomes, including elevated depressive symptoms that compromise quality of life (QoL). While the literature has suggested social support as a protective psychological mechanism, its role in depressive symptoms and QoL among women with infertility remains underexplored. This study aimed to examine the moderating effect of perceived social support on the relationship between depressive symptoms and QoL among South Korean women experiencing infertility.
View Article and Find Full Text PDFDisparities in Trauma Care for Latino Patients: An Analysis by Trauma Center Verification Level.
Cureus
December 2024
Trauma and Acute Care Surgery, Riverside Community Hospital, Riverside, USA.
Introduction Trauma is the leading cause of death for individuals under 45 in the United States (US), with significant disparities in outcomes among minority groups. Latinos, the largest ethnic minority in the US, often face barriers to optimal trauma care that may require additional resources. This study aimed to compare trauma outcomes for Latino patients treated at Level I versus Level II/III trauma centers (TCs).
View Article and Find Full Text PDFUnveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology.
Front Microbiol
January 2025
Department of Biochemistry, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Agra, India.
A significant global health crisis is predicted to emerge due to antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic resistance necessitates continuous therapeutic innovation as conventional antibiotic treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative to synthetic antibiotics.
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