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QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep.
Sci Rep
January 2025
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, Jabłonna, 05-110, Poland.
Since the early discovery of QRFP43, intensive research has been primarily focused on its role in the modulation of food intake. As is widely recognised, the regulation of the body's energy status is a highly complex process involving numerous systems, hormones and neurotransmitters. Among the most important regulators of energy status, alongside the satiety and hunger centre located in the hypothalamus, is the HPT axis, which directly and indirectly affects the regulation of metabolism in all cells of the body.
View Article and Find Full Text PDFRole of Thyrotropin-Releasing Hormone Stimulation Test and Autoantibody in 952 Subjects with Subclinical Hypothyroidism.
J Endocr Soc
November 2024
Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Seoul 04401, Korea.
Context: Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) levels and normal free thyroxine (fT4) levels. In upper normal TSH levels, thyrotropin-releasing hormone (TRH) stimulation test proved to be useful in identifying an exaggerated TSH response.
Objective: We aimed to evaluate the incidence and predictive ability of basal TSH, anti-thyroid peroxidase antibodies (TPOAb), and anti-thyroglobulin antibodies (TgAb) for exaggerated TRH stimulation test in SCH.
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons.
J Transl Med
December 2024
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei, China.
Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine release within the striatum. However, the underlying mechanism remains unclear. In this study, a variety of in vivo and in vitro methods, including transcriptomic analysis, were employed to elucidate the effects of Taltirelin on cellular composition and signaling pathways in the striatum of hemi-PD rats.
View Article and Find Full Text PDFMyeloperoxidase and Thyrotropin-Releasing Hormone Within Leukaemia Stem Cells Increased Chemosensitivity in Acute Myeloid Leukaemia.
J Cell Mol Med
December 2024
Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
Leukaemia stem cells (LSCs) are major contributors to chemoresistance in acute myeloid leukaemia (AML). Identifying potential biomarkers within LSCs that can predict chemosensitivity in AML is key. This prospective study involved 20 consecutive de novo AML patients who underwent '7 + 3' induction therapy.
View Article and Find Full Text PDFA transient neurohormonal circuit controls hatching in fish.
Science
December 2024
Department of Aquaculture and Poultry, Institute of Animal Sciences, Agricultural Research Organization, Volcani Center, Rishon Letziyon, Israel.
Article Synopsis
- Hatching is a crucial event for egg-laying species, timed to enhance survival during early life stages.
- Researchers discovered that thyrotropin-releasing hormone (Trh) triggers hatching in zebrafish by creating a temporary circuit that delivers the hormone into the embryo's bloodstream.
- The study also found that Trh stimulates hatching in a related fish species, highlighting a long-evolved neuroendocrine mechanism controlling this important life event in oviparous fish.
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