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The role of leptin in the etiopathogenesis of anorexia nervosa and bulimia.
Eat Weight Disord
June 2003
Department of Medical and Specialist Sciences, Psychiatric Division, University of Catania, Azienda Policlinico, Catania, Italy.
Leptin is an adipocyte-derived signal factor (167 amino acid protein) encoded by the ob gene in chromosome 7q31 that regulates eating behaviour via central neuroendocrine mechanisms. It has been shown that serum leptin levels correlate with weight and percentage body fat in normal and obese individuals, but the exact correlation between leptin and body weight in anorexic and bulimic patients has not yet been clarified. We investigated leptin levels in the serum of 58 female subjects aged 15-36 years: 10 with bulimia nervosa (BN); 12 with anorexia nervosa (AN); 12 overweight controls (not BN); 12 weight-reduced controls (not AN); and 12 normal weight controls.
View Article and Find Full Text PDF[Erythrocyte zinc-protoporphyrin content in pregnancy].
Minerva Ginecol
May 1993
Laboratorio Analisi Chimico-Cliniche e Microbiologia, USSL 46, Ospedale S. Salvatore, Santhià, Vercelli.
The assessment of iron deficiency represents a major aspect of routine laboratory chemico-clinical analysis, but the results provided by traditional hemato-clinical tests (sideremia, transferrinemia, mean cell volume and red blood cell levels) may not prove conclusive. During pregnancy iron deficiency is common and it would be extremely valuable to obtain a precise method of evaluating anemia. The assay of erythrocytic zincoprotoporphyrin (ZNPP) offers further diagnostic possibilities.
View Article and Find Full Text PDFBlood iron, total transferrin, iron-bound transferrin and transferrin iron saturation percentage were determined in non-anaemic subjects after oral administration of 1 and 2 tablets of a commercial preparation (Ferro-grad) containing ferrous sulphate and ensuring slower release of iron in the intestine. After 1 tablet, blood iron and transferrin saturation reached their peaks after 4 hr and returned to start levels after 10 hr. Higher increases were achieved, though later, with 2 tablets and the return to start levels presumibly occurred within 14 hr.
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