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Experiments were done to test the hypothesis that emptying the gallbladder prior to intravenous cholangiography (IVC) would result in earler and better opacification of the gallbladder. Five dogs were studied on two separate days in a crossover experiment. Each dog had a standard IVC (15-minute infusion of meglumine iodipamide) 2.5 cc/kg of following a 14-16-hour fasting period. On one of the days, 0.3 mcg/kg of Ceruletide was intramuscularly administered to each dog 30 to 45 minutes prior to the iodipamide infusion. Films obtained at the end of infusion and at 20, 40, 60, and 90 minutes were evaluated independently by three radiologists. The results indicate that pretreatment with Ceruletide produces a significant (p less than 0.05) improvement in the quality of gallbladder opacification during the first 90 minutes following iodipamide infusion. We conclude that earlier and better opacification of the gallbladder during IVC can be obtained by prior emptying of the gallbladder with a cholecystokinetic agent.
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| http://dx.doi.org/10.1097/00004424-197909000-00008 | DOI Listing |
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Article Synopsis
- - The study examined gallbladder emptying and GLP-1 hormone responses in women with gestational diabetes mellitus (GDM) during pregnancy and postpartum to understand GDM's impact on these processes.
- - Twenty women (15 with GDM and 15 with normal glucose tolerance) participated in mixed meal tests, revealing no differences in gallbladder emptying or GLP-1 responses between the two groups during pregnancy or after.
- - Results showed that while gallbladder volume and emptying increased significantly during pregnancy, GLP-1 responses decreased, indicating that changes in gallbladder function may not be the main factors contributing to reduced GLP-1 levels in women with GDM.
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