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Biological Activity of Peptide Fraction Derived from L. (Diptera: Stratiomyidae) Larvae Haemolymph on Gastric Cancer Cells.
Int J Mol Sci
February 2025
Department of Basic and Applied Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Gastric cancer (GC) is one of the leading causes of cancer-related mortality worldwide, characterised by poor prognosis and limited responsiveness to chemotherapy. There is a need for new and more effective anticancer agents. Antimicrobial peptides (AMPs) represent a promising class of biomolecules for this purpose.
View Article and Find Full Text PDFNew perspectives on gastric disorders: the relationship between innate lymphoid cells and microbes in the stomach.
Cell Mol Life Sci
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Precision Immune Regulation RIKEN ECL Research Unit, Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan.
A growing number of studies in recent years have revealed the changes in the gastric microbiota during the development of gastric diseases, breaking the stereotype that the stomach is hostile to microorganisms beyond H. pylori. After a decade of intensive research, the discovery of innate lymphoid cells (ILCs) has provided a new perspective on the immune response in many diseases.
View Article and Find Full Text PDFInsight into the environmental cues modulating the expression of bacterial toxin-antitoxin systems.
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Univ Rennes, INSERM, BRM - UMR_S 1230, F-35000 Rennes, France.
Bacteria require sophisticated sensing mechanisms to adjust their metabolism in response to stressful conditions and survive in hostile environments. Among them, toxin-antitoxin (TA) systems play a crucial role in bacterial adaptation to environmental challenges. TA systems are considered as stress-responsive elements, consisting of both toxin and antitoxin genes, typically organized in operons or encoded on complementary DNA strands.
View Article and Find Full Text PDFBridging the gap: exploring students' needs, knowledge, and preferences for delivering comprehensive sexuality education in Sierra Leone.
BMC Public Health
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Institute for Development (IfD), Freetown, Western Area, Sierra Leone.
Background: Sierra Leone, like many developing countries, faces challenges in providing comprehensive sexuality education to its students. Despite the growing recognition of the importance of comprehensive sexuality education in promoting sexual health and well-being, there is a lack of standardised and accessible programs in many parts of the country. This study examined the disconnect between students' needs (both perceived and real), their knowledge, and their preferences for delivering comprehensive sexuality education in Sierra Leone.
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