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Integrating scRNA-seq and Visium HD for the analysis of the tumor microenvironment in the progression of colorectal cancer.
Int Immunopharmacol
January 2025
Department of Pathology, Peking University Shenzhen Hospital, Shenzhen, China. Electronic address:
Background: Colorectal cancer (CRC) development is a complex, multi-stage process, transitioning from normal to adenomatous tissue, and then to invasive carcinoma. Despite research, there's a knowledge gap on using high-resolution spatial omics to understand CRC's tumor microenvironment dynamics.
Methods: We used single-cell transcriptomics to study major biological changes and cell interactions in CRC progression.
GLI1-altered mesenchymal tumor of tongue: a case report and literature review.
Hua Xi Kou Qiang Yi Xue Za Zhi
December 2024
Dept. of Pathology, The First Affiliated Hospital of Hainan Medical University, Haikou 570102, China.
GLI1-altered mesenchymal tumors are a relatively rare type of mesenchymal tumor that is common in the head and neck. It is a newly added tumor type in the World Health Organization Tumor Classification of Head and Neck (5th edition). This article reports a case ofGLI1alteredmesenchymal tumor occurring at the left tongue and reviews the relevant literature to summarize the pathological morphological characteristics, immunophenotype, molecular changes, clinical manifestations, and prognosis of the disease.
View Article and Find Full Text PDF[Chinese expert consensus on the pathological diagnosis of interstitial lung disease with transbronchial lung cryobiopsy specimens].
Zhonghua Jie He He Hu Xi Za Zhi
August 2024
Article Synopsis
- Transbronchial lung cryobiopsy (TBLC) is a technique for diagnosing interstitial lung disease (ILD) but raises concerns about accuracy due to smaller sample sizes compared to surgical lung biopsy (SLB).
- A consensus among experts in respiratory and pathological fields was developed, focusing on improving diagnostic practices and outlining procedural guidelines for TBLC, which includes delivery requirements and diagnostic principles.
- The consensus emphasizes the need for adequate specimen size (greater than 5 mm in diameter) and recommends multiple pieces to ensure quality, along with specific criteria for microscopic evaluation to enhance diagnostic accuracy.
Butyrate attenuates cold-induced hypertension via gut microbiota and activation of brown adipose tissue.
Sci Total Environ
September 2024
Institute of Occupational Health and Environmental Health, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, People's Republic of China; Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Bureau, Shanghai 200030, People's Republic of China; Shanghai Typhoon Institute, China Meteorological Administration, Shanghai 200030, People's Republic of China. Electronic address:
Objective: Chronic exposure to cold temperature is known to elevate blood pressure, leading to a condition known as cold-induced hypertension (CIH). Our previous research suggested correlations between alterations in gut microbiota, decrease in butyrate level, and the onset and progression of CIH. However, the role of butyrate in CIH and the underlying mechanisms need further investigation.
View Article and Find Full Text PDF[Study on mechanism of Aconitum pendulum in treating rheumatoid arthritis based on toxicity efficacy evaluation and metabonomics].
Zhongguo Zhong Yao Za Zhi
April 2024
School of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
The study aims to investigate the effects and potential mechanism of raw and processed Aconitum pendulum Busch on rheumatoid arthritis(RA) and analyze their toxicity attenuating and efficacy retaining effects. The bovine type Ⅱ collagen-induced arthritis(CIA) rat model was established. The weight, cardiac index, immune organ index, and arthritis index of the rats were recorded and calculated after administration.
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