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The rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014-2022 for genomic and phenotypic antimicrobial resistance.
View Article and Find Full Text PDFCarriage and antimicrobial susceptibility of commensal Neisseria species from the human oropharynx.
Sci Rep
October 2024
Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London, UK.
Commensal Neisseria (Nc) mainly occupy the oropharynx of humans and animals. These organisms do not typically cause disease; however, they can act as a reservoir for antimicrobial resistance genes that can be acquired by pathogenic Neisseria species. This study characterised the carriage and antimicrobial susceptibility profiles of Nc from the oropharynx of 50 participants.
View Article and Find Full Text PDFAssessing novel partner antimicrobials to protect ceftriaxone against gonococcal resistance: An in vitro evaluation.
Int J STD AIDS
November 2024
STI Unit, Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Article Synopsis
- Scientists studied how to fight bacteria that are resistant to a medicine called ceftriaxone.
- They tested different drugs to see if they could work together with ceftriaxone to stop the bacteria from becoming resistant.
- The results showed that two specific drugs, zoliflodacin and pristinamycin, could help reduce the chances of ceftriaxone resistance spreading.
Global trends of antimicrobial resistance rates in : a systematic review and meta-analysis.
Front Pharmacol
July 2024
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background: Antimicrobial resistance (AMR) of (NG) is a significant public health concern.
Objective: The objective of our study was to assess global AMR rates and test them both temporally and geographically.
Methods: We conducted a systematic search of relevant reports from international databases up to 2021.
Risk factors associated with increasing prevalence of gonorrhea and the antimicrobial susceptibility profiles of among adolescents: A decade-long, hospital-based study from India.
Indian J Sex Transm Dis AIDS
June 2024
Department of Dermatology and STD, Apex Regional STD Centre, Safdarjung Hospital, New Delhi, India.
Background: Gonorrhea is a significant cause of morbidity among sexually active population. Young adults and adolescents have a high risk of contracting sexually transmitted infections (STIs) due to behavioral, biological, and cultural factors fuelling the epidemic among them. The Centers for Disease Control recommends annual STI screening for sexually active individuals under twenty-five and those at higher risk.
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