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Simple vs Complex Aortic Arch Repair in Acute Type A Aortic Dissection.
J Am Coll Surg
January 2025
University of Florida Health, Division of Cardiovascular Surgery, Department of Surgery, Gainesville, Florida USA.
Background: The purpose of this study is to evaluate the clinical outcomes of patients undergoing a simpler (hemiarch) vs complex (zone 2 arch) aortic repair for acute type A aortic dissection (TAAD).
Methods: Adults (≥18 years) who underwent hemiarch or zone 2 arch repair for acute, hyperacute, or acute on chronic TAAD at a single institution between January 2018 and April 2024 were reviewed. Disabling stroke was defined as modified Rankin scale ≥4.
Walter Brendel and the dawn of transplantation research in Germany.
Front Transplant
September 2024
German Academy for Transplantation Medicine, Munich, Germany.
Walter Brendel was a physiologist who headed the Institut of Experimental Surgery at the University of Munich (LMU) from 1961 until 1989. His legendary career began with the development of an anti-human lymphocyte globulin (ALG) at his Institute during the late 1960s. The initial successful treatment of a small number of patients culminated in the co-treatment of the first successfully heart-transplanted patient in Capetown, South Africa (successful reversal with ALG of an acute allograft rejection).
View Article and Find Full Text PDFAcute hepatitis A with haemophagocytic lymphohistiocytosis: G-6PD deficiency-induced haemolytic anaemia and bile cast nephropathy.
BMJ Case Rep
September 2024
Internal Medicine, Baby Memorial Hospital, Calicut, Kerala, India.
Article Synopsis
- Hepatitis A virus (HAV) usually causes mild illness but can lead to severe complications like acute liver failure, which is fatal in rare cases; in 2016, it resulted in about 7,134 deaths.
- Fulminant liver failure occurs in less than 1% of acute hepatitis A cases, but unusual associations with other severe conditions like haemophagocytic lymphohistiocytosis (HLH) have been noted.
- The case presented discusses a man in his 30s with G6PD deficiency, whose acute HAV infection led to severe symptoms, including hyperacute liver failure, HLH, and renal failure.
Renal allograft failure resulting from diffuse cortical necrosis.
Indian J Pathol Microbiol
June 2024
Department of Pathology, Uropathology Division, Surgical Pathology Laboratory, Seth G.S. Medical College and K.E.M Hospital, Parel, Mumbai, Maharashtra, India.
Cortical necrosis of the renal allograft is an extremely rare but serious complication of renal transplantation and can lead to graft failure. Few cases have been reported in the literature to date. We present a rare case of a 28-year-old woman with chronic kidney disease for the past four years who was on biweekly hemodialysis and referred to our tertiary care center for a living-related renal transplant.
View Article and Find Full Text PDF[Renal xenotransplantation : state of the art].
Rev Med Suisse
February 2024
Service de néphrologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Xenotransplantation could be an inexhaustible source of organs and change the life of end-stage kidney disease patients with reduction of morbidity and mortality. Through genetic engineering it is now possible to reduce the risk of hyperacute and acute graft rejection and improve the overall immune compatibility between two different species. Some experiments have already brought promising perspectives.
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