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IFN-I promotes T cell-independent immunity and RBC autoantibodies via modulation of B-1 cell subsets in murine SCD.
Blood
December 2024
New York Blood Center, New York, New York, United States.
The pathophysiology of sickle cell disease (SCD) is characterized by hemolytic anemia and vaso-occlusion, although its impact on the adaptive immune responses remains incompletely understood. To comprehensibly profile the humoral immune responses, we immunized SCD mice with T cell-independent (TI) and T cell-dependent (TD) antigens. Our study showed that SCD mice have significantly enhanced type 2 TI (TI-2) immune responses in a manner dependent on the level of type I IFN (IFN-I), while maintaining similar or decreased TD immune responses depending on the route of antigen administration.
View Article and Find Full Text PDFManagement of Red Cell Alloimmunization in Pregnancy.
Obstet Gynecol
October 2024
Department of Women's Health, Dell Medical School, UT Health Austin, and the Comprehensive Fetal Center, Dell Children's Medical Center, Austin, Texas; and the Department of Obstetrics and Gynecology, Bridgeport Hospital/Yale University, Bridgeport, Connecticut.
Rhesus immune globulin has resulted in a marked decrease in the prevalence of RhD alloimmunization in pregnancy; however, antibody formation to other red cell antigens continues to occur. Evaluation for the presence of anti-red cell antibodies should be routinely undertaken at the first prenatal visit. If anti-red cell antibodies are detected, consideration of a consultation or referral to a maternal-fetal medicine specialist with experience in the monitoring and treatment of these patients is warranted.
View Article and Find Full Text PDFImpact of human leucocyte antigen class II polymorphism on anti-red blood cell antibody development: Correlations and indications.
Vox Sang
July 2024
Tissue Typing Department, Blood Transfusion Institute of Serbia, Belgrade, Serbia.
Backround And Objectives: Blood transfusion therapy is vital for many patient groups. They can cause many complications, and the development of anti-red blood cell (RBC) antibodies is of significant importance. Molecules of class II human leucocyte antigens (HLA) are one of the several factors that influence antibody development in patients.
View Article and Find Full Text PDFHereditary TTP/Upshaw-Schulman syndrome: the ductus arteriosus controls newborn survival.
Int J Hematol
May 2024
Department of Blood Transfusion Medicine, Nara Medical University, Shijyo-Cho 840, Kashihara, Nara, Japan.
Hereditary TTP (hTTP), termed Upshaw-Schulman syndrome, is an ultra-rare disorder caused by a severe deficiency of plasma ADAMTS13 activity that allows circulation of ultra-large von Willebrand factor (UL-VWF) multimers. The greatest risk for hTTP is in their first days after birth, when 35-50% of patients will have severe hemolysis, jaundice, and thrombocytopenia. It is often fatal without effective treatment.
View Article and Find Full Text PDFPresence of anti-RBC antibodies correlates with parasitaemia and once-infected RBCs but not the extent of post-malaria haemolysis.
J Travel Med
December 2024
Department of Infectious Diseases and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 13353 Berlin, Germany.
In a cohort of patients treated with oral artemisinin combination therapy for uncomplicated malaria, the presence of anti-red blood cell (RBC) auto-antibodies does not correlate with the extent of post-treatment haemolysis. Patients with positive antibody screening test on d14 had higher initial parasitaemia and a higher number of once-infected RBCs throughout follow-up.
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