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Impaired Thiamine Metabolism in Amyotrophic Lateral Sclerosis and Its Potential Treatment With Benfotiamine: A Case Report and a Review of the Literature.
Cureus
June 2023
Podiatry, Realm Labs, LLC, Boca Raton, USA.
Homogenates of brain tissue from the frontal cortex at autopsy in patients with amyotrophic lateral sclerosis (ALS) showed dramatically reduced levels of the enzyme thiamine pyrophosphatase (TPPase), the enzyme responsible for the conversion of thiamine pyrophosphate (TPP) to thiamine monophosphate (TMP). Additionally, free thiamine (vitamin B1) and TMP levels have been shown to be significantly reduced in the plasma and cerebral spinal fluid (CSF) of patients with ALS. These findings suggest that there is impaired thiamine metabolism in patients with ALS.
View Article and Find Full Text PDFPyruvate decarboxylase and thiamine biosynthetic genes are regulated differently by Pdc2 in S. cerevisiae and C. glabrata.
PLoS One
June 2023
Department of Biology, Villanova University, Villanova, Pennsylvania, United States of America.
Understanding metabolism in the pathogen Candida glabrata is key to identifying new targets for antifungals. The thiamine biosynthetic (THI) pathway is partially defective in C. glabrata, but the transcription factor CgPdc2 upregulates some thiamine biosynthetic and transport genes.
View Article and Find Full Text PDFOrganic secretion in ductal cells of the sublingual salivary gland of ferret: Histochemical observations.
Acta Histochem
May 2020
School of Dentistry, University of Liverpool, Liverpool, United Kingdom.
Article Synopsis
- The study investigates the presence of organic secretion in the ductal cells of the sublingual salivary gland in ferrets, which previously had unclear evidence.
- Histological analysis revealed granulated substances rich in specific amino acids and enzymes in the ductal cells, indicating unique organelle activity, varying within different ducts and cells.
- Findings suggest that these substances and enzymes, including tissue kallikrein, point towards a localized protein-bound amino acid secretion in ferret sublingual ductal cells, supported by the presence of nerve fibers around the ducts.
Unraveling RNA dynamical behavior of TPP riboswitches: a comparison between Escherichia coli and Arabidopsis thaliana.
Sci Rep
March 2019
Computational Biophysics and Molecular Modeling Group. Scientific Computing Program (PROCC), Fundação Oswaldo Cruz, Rio de Janeiro, 21040-222, Brazil.
Riboswitches are RNA sensors that affect post-transcriptional processes through their ability to bind to small molecules. Thiamine pyrophosphate (TPP) riboswitch class is the most widespread riboswitch occurring in all three domains of life. Even though it controls different genes involved in the synthesis or transport of thiamine and its phosphorylated derivatives in bacteria, archaea, fungi, and plants, the TPP aptamer has a conserved structure.
View Article and Find Full Text PDFIntegrative method for three-dimensional imaging of the entire Golgi apparatus by combining thiamine pyrophosphatase cytochemistry and array tomography using backscattered electron-mode scanning electron microscopy.
Biomed Res
June 2018
Department of Microscopic Anatomy and Cell Biology, Asahikawa Medical University.
Thiamine pyrophosphatase (TPPase) cytochemistry is an established method for specific labeling of the trans-Golgi cisterns in tissue sections. Herein, we combined this enzyme cytochemical method with array tomography using scanning electron microscopy (SEM), a new imaging technique based on collection of backscattered electron (BSE) images of consecutive resin-embedded sections on glass slides, to detect the entire three-dimensional (3D) organization of the Golgi apparatus with sufficient spatial resolution. As the signal intensity of BSE depends on the atomic number of the materials, lead precipitates confined to the trans-Golgi cisterns after TPPase cytochemistry were clearly observed by BSE-mode SEM.
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