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Reversal of Diabetic Dry Eye by Topical Opioid Receptor Blockade Follows Dual Pathways.
Invest Ophthalmol Vis Sci
March 2025
Department of Neuroscience and Experimental Therapeutics, Penn State University College of Medicine, Hershey, Pennsylvania, United States.
Purpose: To determine pathways in the trigeminal ganglion and corneal epithelium that are targeted by topical naltrexone (NTX) treatment for dry eye.
Methods: NTX drops were administered topically daily for 15 days to the corneal surface of male and female adult type 1 diabetic rats. Schirmer scores and corneal sensitivity were measured at baseline, 5, 10, and 15 days.
Targeting the Contact-Kinin System: A Cyclopeptide with Anti-Thromboinflammatory Properties Against Stroke.
Eur J Pharmacol
March 2025
Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Sino-African Joint Research Center, and Kunming Institute of Zoology, Chinese Academy of Sciences, No. 17 Longxin Road, Kunming 650201, Yunnan, China. Electronic address:
The contact-kinin system plays a central role in the thromboinflammatory pathology of ischemic stroke. Modulating this pathway represents a promising strategy for the prevention and treatment of ischemic stroke. Based on our recent findings demonstrating that the short peptide SD6 (SLGASD), derived from a specific influenza-related immunoglobulin heavy chain junction region sequence, exhibits anti-coagulant properties, we designed a cyclized version, cycloSD6, and evaluated its anti-ischemic stroke potential.
View Article and Find Full Text PDFBradykinin B1 receptor signaling triggers complement activation on endothelial cells.
Front Immunol
February 2025
Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.
Introduction: The complement and kallikrein-kinin systems (KKS) are both activated during vascular inflammation, and there are many known interactions between the two systems. This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent on bradykinin B1 receptor (B1R) signaling.
Methods: KKS was activated in normal human serum by kaolin or activated factor XII (FXIIa).
Mutations in apolipoprotein L1 (APOL1) are strongly associated with an increased risk of kidney disease in individuals of African ancestry, yet the underlying mechanisms remain largely unknown. Plasma proteomics provides opportunities to elucidate mechanisms of disease by studying the effects of disease-associated variants on circulating protein levels. Here, we examine the genetic drivers of circulating APOL1 in individuals of African and European ancestry from four independent cohorts (UK Biobank, AASK, deCODE and Health ABC) employing three proteomic technologies (Olink, SomaLogic and mass spectrometry).
View Article and Find Full Text PDFKeratin 1 modulates intestinal barrier and immune response kallikrein kinin system in ulcerative colitis.
World J Gastroenterol
February 2025
Department of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Province Clinical Research Center for Digestive Diseases, Kunming 650032, Yunnan Province, China.
Background: External factors in ulcerative colitis (UC) exacerbate colonic epithelial permeability and inflammatory responses. Keratin 1 (KRT1) is crucial in regulating these alterations, but its specific role in the progression of UC remains to be fully elucidated.
Aim: To explore the role and mechanisms of KRT1 in the regulation of colonic epithelial permeability and inflammation in UC.
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