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Placental and serum levels of human α-Klotho in preeclampsia & intra-uterine growth retardation: A potential sensitive biomarker?
Pregnancy Hypertens
June 2024
Azrieli Faculty of Medicine, Safed, Bar Ilan University, Ramat-Gan, Israel; Cardiovascular Laboratory, Medical Research Institute, The Galilee Medical Center, Nahariya, Israel. Electronic address:
Introduction: α-Klotho protein has three isoforms: a transmembrane (mKL), a shed- soluble isoform, and a circulating soluble isoform (sKL). mKL is expressed in the kidney and placenta, while sKL is detectable in blood and urine. It is known that α-Klotho levels fluctuate during pregnancy mainly in women with complications such as preeclampsia (PE) and intra-uterine growth restriction (IUGR).
View Article and Find Full Text PDFHypertensive Disorders in Pregnancy Current Practice Review.
Curr Hypertens Rev
April 2019
Department of Obstetrics, University of California Irvine - California, CA 90012. United States.
Background: Hypertensive disorders (preeclampsia, eclampsia, gestational hypertension, and chronic hypertension with superimposed preeclampsia) complicate 3-5% of all pregnancies and are a significant cause of maternal mortality and morbidity. Preeclampsia is a multi-system disorder characterised by new onset hypertension after the 20th week of pregnancy with proteinuria. Proteinuria is defined as 300 mg or more of protein in a 24-hour urine collection or a protein: creatinine ratio of 0.
View Article and Find Full Text PDFAdhesive and degradative properties of human placental cytotrophoblast cells in vitro.
J Cell Biol
August 1989
Department of Stomatology, University of California, San Francisco 94143.
Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties. Thus, during early pregnancy fetal cytotrophoblast cells invade the uterus and its arterial network.
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