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Maternal cell-free DNA in early pregnancy for preeclampsia screening: a systematic review.
Arch Gynecol Obstet
January 2025
Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Purpose: To quantify the separation between maternal blood cell-free (cf)DNA markers in preeclampsia and unaffected pregnancies and compare with existing markers. This approach has not been used in previous studies.
Methods: Comprehensive systematic literature search of PubMed to identify studies measuring total cfDNA, fetal cf(f)DNA or the fetal fraction (FF) in pregnant women.
Modulation of placental angiogenesis by metformin in a rat model of gestational diabetes.
Histochem Cell Biol
January 2025
Medical Histology and Cell Biology Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Gestational diabetes mellitus (GDM) significantly disrupts placental structure and function, leading to complications such as intrauterine growth restriction (IUGR) and preeclampsia. This study aimed to investigate the effects of GDM on placental histology, angiogenesis, and oxidative stress, as well as evaluate metformin's protective role in mitigating these changes. A total of 60 pregnant Sprague-Dawley rats were divided into four groups: control, metformin-treated, GDM, and GDM with metformin.
View Article and Find Full Text PDFSequestration of parasites in the placental vasculature causes increased morbidity and mortality in pregnant compared to non-pregnant patients in malaria- endemic regions. In this study, outbred pregnant CD1 mice with semi allogeneic fetuses were infected with transgenic or mock-inoculated by mosquito bite at either embryonic day (E) 6 (first trimester-equivalent) or 10 (second trimester- equivalent) and compared with non-pregnant females. -infected mosquitoes had greater biting avidity for E10 dams than uninfected mosquitoes, which was not apparent for E6 dams nor non-pregnant females.
View Article and Find Full Text PDFExploring Barriers and Bridging Gaps: Perspectives of Nurses, Midwives, and Lady Health Workers in the Implementation of Emergency Obstetric Care.
Pak J Med Sci
January 2025
Prof. Dr. Shehla Noor, Department of obstetrics & Gynaecology, Ayyub Medical College, Abbottabad, Pakistan.
Background & Objectives: Maternal mortality is a global concern primarily due to preventable obstetric complications. Challenges in implementing Emergency Obstetric Care (EmOC) in developing nations hinder effective reduction of these deaths. Our objective was to identify key challenges in EmOC practices among frontline healthcare providers, assess the severity and frequency of these barriers, and evaluate gaps in resources, training, and institutional support needed for effective resolution.
View Article and Find Full Text PDFCorrelation between the severity of endometriosis and the occurrence of placenta accreta spectrum in the subsequent pregnancy.
Pak J Med Sci
January 2025
Shunhe Lin Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology Pediatrics, Fujian Medical University, Fuzhou, Fujian Province 350001, P.R. China.
Objective: To investigate the correlation between endometriosis (EMs) severity and placenta accreta spectrum (PAS) risk in the subsequent pregnancy.
Method: Clinical records of 2,142 patients who underwent laparoscopic surgery for EMs at Fujian Provincial Maternal and Child Health Hospital from January 2014 to January 2018, who had achieved pregnancy and were delivered, were analyzed. Baseline data, EMs stage, The Revised American Fertility Society (R-AFS) score, levels of serum indexes, and pregnancy and neonatal outcomes were recorded.
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