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A core glycolipid vaccine elicits cross-reactive antibodies against Salmonella spp. and protects against invasive nontyphoidal Salmonella disease in mice.
J Infect Dis
December 2024
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Background: Enteric fever caused by Salmonella enterica serovars Typhi and Paratyphi A in addition to gastroenteritis and invasive disease, predominantly attributable to nontyphoidal Salmonella serovars Typhimurium and Enteritidis, are major causes of death and disability across the globe. A broad-spectrum vaccine that protects against disease caused by typhoidal and nontyphoidal serovars of Salmonella is not available for humans but would prevent a considerable burden of disease worldwide.
Methods: We previously developed a broad-spectrum vaccine for Gram-negative bacteria that is based on the inner core domain of detoxified Escherichia coli O111, Rc (J5) mutant lipooligosaccharide, a highly conserved antigen across Gram-negative bacteria, complexed with an outer membrane protein of group B Neisseria meningitidis.
Enhanced Expression of the Gene of Vaccinia Virus by the tPA Signal Sequence Inserted in a Fowlpox-Based Recombinant Vaccine.
Vaccines (Basel)
September 2024
Department of Pharmacy, Faculty of Pharmacy, Catholic University "Our Lady of Good Counsel", Rr. Dritan Hoxha, 123, 1001 Tirana, Albania.
Article Synopsis
- The study discusses the role of Vaccinia virus (VACV) in eradicating smallpox and highlights the importance of the L1 protein in vaccination efforts.
- Researchers developed a new fowlpox-based recombinant vaccine that links a signal sequence to enhance the expression and secretion of the L1 protein.
- The findings suggest that this approach could improve the immunogenicity of vaccines targeting the L1 protein, making them more effective in providing immunity against smallpox.
Production and characterization of biologicals for disease diagnosis and pathological evaluation of elephant endotheliotropic herpesvirus (EEHV).
J Virol Methods
September 2024
CADRAD, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Elephant endotheliotropic herpesviruses (EEHV) belong to the family Herpesviridae and cause a highly fatal hemorrhagic infection in elephants. EEHV poses a global threat to the already endangered elephant population. Since EEHV is a non-cultivable virus, there is a scarcity of specific diagnostics, therapeutics, and vaccines.
View Article and Find Full Text PDFIsolation and characterization of a Mannheimiahaemolytica secreted serine protease that degrades sheep and bovine fibrinogen.
Microb Pathog
July 2024
Facultad de Estudios Superiores Iztacala, UNAM, Av. De Los Barrios 1, Los Reyes Iztacala, 54090, Tlalnepantla, Edo de México, Mexico. Electronic address:
Mannheimiahaemolytica is an opportunistic agent of the respiratory tract of bovines, a member of the Pasteurellaceae family, and the causal agent of fibrinous pleuropneumonia. This bacterium possesses different virulence factors, allowing it to colonize and infect its host. The present work describes the isolation and characterization of a serine protease secreted by M.
View Article and Find Full Text PDFEffects of Adjuvant and Immunization Route on Antibody Responses against Venom.
Arch Razi Inst
August 2023
Department of Venomous Animals and Antivenom Production, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.
(NNO) is one of the important venomous species in Iran. The current snakebite treatment is antivenom therapy that deals with hyper immunization of horses with crude or fractionated snake venom plus traditional adjuvants, like Freund's adjuvant. For improvement of antivenom production, it has been suggested to use different adjuvant systems or immunization procedures.
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