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Thalamic functional connectivity on 7-Tesla magnetic resonance imaging and its relation to motor signs in early-stage Parkinson's disease.
Quant Imaging Med Surg
January 2025
School of Medicine, Nankai University, Tianjin, China.
Background: It is well known that dysfunction of thalamocortical circuity generates the motor signs that lead to distinct disease processes and prognoses in Parkinson's disease (PD). This study aimed to leverage ultrahigh-field magnetic resonance imaging (MRI) to identify the connectivity alterations of thalamocortical circuity and clarify their relation to motor signs in early PD.
Methods: Patients with early-stage PD (n=55) and healthy controls (HCs, n=56) were recruited from March 2022 to July 2023.
Sensitivity of Functional Arterial Spin Labelling in Detecting Cerebral Blood Flow Changes.
Br J Hosp Med (Lond)
December 2024
Department of Neurology, Wuhan Brain Hospital, General Hospital of Yangtze River Shipping, Wuhan, Hubei, China.
Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) method. ASL techniques can quantitatively measure cerebral perfusion by fitting a kinetic model to the difference between labelled images (tag images) and ones which are acquired without labelling (control images). ASL functional MRI (fMRI) provides quantitative perfusion maps by using arterial water as an endogenous tracer instead of depending on vascular blood oxygenation level.
View Article and Find Full Text PDFA machine learning approach to automate microinfarct and microhemorrhage screening in hematoxylin and eosin-stained human brain tissues.
J Neuropathol Exp Neurol
February 2025
Department of Pathology and Laboratory Medicine, University of California Davis, Sacramento, CA, United States.
Microinfarcts and microhemorrhages are characteristic lesions of cerebrovascular disease. Although multiple studies have been published, there is no one universal standard criteria for the neuropathological assessment of cerebrovascular disease. In this study, we propose a novel application of machine learning in the automated screening of microinfarcts and microhemorrhages.
View Article and Find Full Text PDFStructure of subcortico-cortical tracts in middle-aged and older adults with autism spectrum disorder.
Cereb Cortex
December 2024
Brain Development Imaging Laboratories, Department of Psychology, San Diego State University, 6363 Alvarado Ct., San Diego, CA 92120, United States.
Middle-aged and older adults with autism spectrum disorder may be susceptible to accelerated neurobiological changes in striato- and thalamo-cortical tracts due to combined effects of typical aging and existing disparities present from early neurodevelopment. Using magnetic resonance imaging, we employed diffusion-weighted imaging and automated tract-segmentation to explore striato- and thalamo-cortical tract microstructure and volume differences between autistic (n = 29) and typical comparison (n = 33) adults (40 to 70 years old). Fractional anisotropy, mean diffusivity, and tract volumes were measured for 14 striato-cortical and 12 thalamo-cortical tract bundles.
View Article and Find Full Text PDFElectroencephalography based delirium screening in acute supratentorial stroke.
BMC Neurol
November 2024
Department of Neurology, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Arnold-Heller-Straße 3, 24105, Kiel, Germany.
Background: Up to 25% of patients suffering from an acute stroke are diagnosed with delirium during the hospital stay, with older age increasing the risk. Generalized slowing in the electroencephalogram (EEG) supports the diagnosis of delirium. We examined the potential of single-channel EEG (DeltaScan) as an easy-to-use device on intensive care units for detecting delirium.
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