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Implementation of an algorithm for testing, diagnosis, and antibiotic stewardship of asymptomatic bacteriuria in pregnancy.
Am J Obstet Gynecol MFM
November 2024
Department of Clinical Laboratory Sciences, The University of Texas Medical Branch, Galveston, TX (Bergbower and Rajendran). Electronic address:
Article Synopsis
- - Asymptomatic bacteriuria affects a notable percentage of pregnant women, with some developing symptomatic urinary tract infections (UTIs) that carry risks like low birthweight and preterm delivery.
- - Current methods for detecting UTIs, including urine cultures and dipstick tests, have limitations, particularly in interpreting results for asymptomatic bacteriuria, highlighting the need for more reliable diagnostic guidelines.
- - The study aims to create and assess an evidence-based algorithm to improve the interpretation of urinalysis results and treatment decisions for asymptomatic bacteriuria among pregnant patients during routine obstetric visits.
Initial empirical antibiotic therapy in kidney transplant recipients with pyelonephritis: A global survey of current practice and opinions across 19 countries on six continents.
Transpl Infect Dis
December 2024
Transplant Infectious Disease and Compromised Host Program, Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Background: Despite the burden of pyelonephritis after kidney transplantation, there is no consensus on initial empirical antibiotic management.
Methods: We surveyed clinicians throughout the world on their practice and opinions about the initial empirical therapy of post-transplant pyelonephritis, using clinical vignettes. A panel of experts from 19 countries on six continents designed this survey, and invited 2145 clinicians to participate.
Real-World Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System Database for Asciminib.
Oncology
December 2024
Department of Pharmacy, Pingtan Comprehensive Experimental Area Hospital, Pingtan Comprehensive Experimental Area, Fuzhou, China.
Article Synopsis
- Asciminib is a drug used mainly for treating chronic myeloid leukemia in patients with specific mutations or those who have undergone prior treatments; however, its long-term safety isn't well established.
- This study analyzed adverse events linked to asciminib using the FDA's adverse event reporting system from October 2021 to December 2023, identifying over 900 reported incidents.
- Findings revealed 26 significant adverse events related to off-label use of asciminib, with a median onset of 52.5 days, suggesting a need for further research on its safety profile.
Influence of Kidney Environment Parameters on Antibiotic Efficacy Against Uropathogenic Escherichia coli.
Eur Urol Focus
September 2024
Clinic for Urology, Pediatric Urology and Andrology, Justus-Liebig-University of Giessen, Giessen, Germany; German Center for Infection Research (DZIF), Partner Site Giessen-Marburg-Langen, Giessen, Germany.
Article Synopsis
- Urinary tract infections (UTIs) are commonly caused by bacteria, particularly Escherichia coli, with kidney infections (pyelonephritis) being severe and difficult to treat due to the unique kidney microenvironment.
- The study tested how factors like sodium chloride, urea, and pH levels affect the effectiveness of antibiotics (ertapenem, levofloxacin, and ceftriaxone) against E. coli strains in conditions mimicking the kidney.
- Findings showed that pH significantly affects levofloxacin's effectiveness, while sodium chloride and urea impact various strains differently, highlighting the need for more research on other antibiotics and kidney conditions for better treatment strategies.
Effects of pH on the Pathogenicity of and on the Kidney: In Vitro and In Vivo Studies.
Int J Mol Sci
July 2024
Clinical Unit of Infectious Diseases, Microbiology and Parasitology, Institute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital/CSIC/University of Seville, 41013 Seville, Spain.
Urine pH reflects the functional integrity of the body and may influence the virulence of uropathogenic and , the main causes of urinary tract infections (UTIs). This study evaluated the effects of acidic pH on the pathogenicity of uropathogenic and strains, in vitro and in vivo. Four uropathogenic and four strains were used.
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