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A GC-MS Method for Determination of β-Propiolactone Residues in Inactivated Covid-19 Vaccines.
J Chromatogr Sci
December 2024
Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Engelab Ave, Tehran 14155-6451, Iran.
β-propiolactone is a common inactivator agent used in vaccines. Due to β-propiolactone carcinogenicity, complete hydrolysis of it is necessary to prevent cytotoxicity in mammalian cells. As a result, more attention should be paid to it at the clinic, and it is important to measure its trace amounts.
View Article and Find Full Text PDFDevelopment of a high-performance liquid chromatography using rhodamine B hydrazide as the derivatization reagent for determination of β propiolactone residues in inactivated COVID-19 vaccines.
J Chromatogr B Analyt Technol Biomed Life Sci
August 2024
Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; PharmaBridge, Pharmaceutical Consultancy Company, Jule Stynestraat 102 3543 DS, Utrecht, the Netherlands. Electronic address:
Article Synopsis
- * A new High-Performance Liquid Chromatography-Ultraviolet (HPLC-UV) method was developed using Rhodamine B hydrazide (RBH) as a derivatizing agent, optimized in weak acidic conditions, and successfully separated on a C8 column.
- * The method showed high linearity (r2 > 0.99), low detection limits (0.17 µg/mL), and was applied to analyze BPL residues in inactivated COVID-19 vaccines, promising for quality control and regulatory
β-Propiolactone (BPL)-inactivation of SARS-Co-V-2: In vitro validation with focus on saliva from COVID-19 patients for scent dog training.
J Virol Methods
July 2023
Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hanover, Germany. Electronic address:
β-Propiolactone (BPL) is an organic compound widely used as an inactivating agent in vaccine development and production, for example for SARS-CoV, SARS-CoV-2 and Influenza viruses. Inactivation of pathogens by BPL is based on an irreversible alkylation of nucleic acids but also on acetylation and cross-linking between proteins, DNA or RNA. However, the protocols for BPL inactivation of viruses vary widely.
View Article and Find Full Text PDFPoly(4-ketovalerolactone) from Levulinic acid: Synthesis and Hydrolytic Degradation.
Macromolecules
June 2020
Department of Chemistry, 207 Pleasant Street, SE, University of Minnesota, Minneapolis, Minnesota 55455, United States.
We report here the synthesis of poly(4-ketovalerolactone) () via ring-opening transesterification polymerization (ROTEP) of the monomer 4-ketovalerolactone (, two steps from levulinic acid). The polymerization of proceeds to high equilibrium monomer conversion (up to 96% in the melt) to give the semicrystalline polyketoester with low dispersity. displays glass transition temperatures of 7 °C and two melting temperatures at 132 and 148 °C.
View Article and Find Full Text PDFGas chromatography-mass spectrometry method for determination of -propiolactone in human inactivated rabies vaccine and its hydrolysis analysis.
J Pharm Anal
December 2018
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
A simple method was established for the determination of -propiolactone (BPL) in human inactivated rabies vaccine by gas chromatography-mass spectrometry (GC-MS). The determination was performed on an Agilent HP-INNOWAX (30 m × 0.32 mm i.
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