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Phenotypic and fitness consequences of plasticity in the rhythmic replication of malaria parasites.
Philos Trans R Soc Lond B Biol Sci
January 2025
Institute of Ecology and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
The environments that parasites experience within hosts change dramatically over 24 h. How rhythms shape host-parasite-vector interactions is poorly understood owing to the challenges of disentangling the roles of rhythms of multiple interacting species in the context of the complex lifecycles of parasites. Using canonical circadian clock-disrupted hosts, we probe the limits of flexibility in the rhythmic replication of malaria () parasites and quantify the consequences for fitness proxies of both parasite and host.
View Article and Find Full Text PDFSLAM-seq reveals independent contributions of RNA processing and stability to gene expression in African trypanosomes.
Nucleic Acids Res
December 2024
Division of Experimental Parasitology, Faculty of Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.
Gene expression is a multi-step process that converts DNA-encoded information into proteins, involving RNA transcription, maturation, degradation, and translation. While transcriptional control is a major regulator of protein levels, the role of post-transcriptional processes such as RNA processing and degradation is less well understood due to the challenge of measuring their contributions individually. To address this challenge, we investigated the control of gene expression in Trypanosoma brucei, a unicellular parasite assumed to lack transcriptional control.
View Article and Find Full Text PDFDetection of human IgG antibodies against using a recombinant MG075 antigen.
medRxiv
November 2024
Reproductive Microbiology, Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Copenhagen, Denmark.
Article Synopsis
- The text discusses the development of a serological test to identify a sexually transmitted pathogen that affects reproductive health in both genders.
- It highlights the challenges faced due to cross-reactivity with a similar respiratory pathogen, making accurate testing difficult.
- The newly developed immunoblot assay shows promising results with a sensitivity of 87.1% and specificity of 95.2%, which could enhance understanding of the pathogen's impact on reproductive complications.
Disentangling the effects of intermittent faecal shedding and imperfect test sensitivity on the microscopy-based detection of gut parasites in stool samples.
PLoS Negl Trop Dis
December 2024
Programa de Pós-Graduação em Medicina Tropical, Faculdade de Medicina, Universidade de Brasília, Brasília, Brazil.
Background: Gut-parasite transmission often involves faecal shedding, and detecting parasites in stool samples remains the cornerstone of diagnosis. However, not all samples drawn from infected hosts contain parasites (because of intermittent shedding), and no test can detect the target parasites in 100% of parasite-bearing samples (because of imperfect sensitivity). Disentangling the effects of intermittent shedding and imperfect sensitivity on pathogen detection would help us better understand transmission dynamics, disease epidemiology, and diagnostic-test performance.
View Article and Find Full Text PDFParasite traits, host traits, and environment as determinants of dark diversity affinity in flea and gamasid mite assemblages from the Palearctic.
Parasitol Res
November 2024
French Associates Institute for Agriculture and Biotechnology of Drylands, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, Midreshet Ben-Gurion, Israel.
A species set in a site comprises species that are present (realized diversity) and species that could inhabit this site but are absent (dark diversity; DD). DD can be both species-driven (a species' traits preclude its presence, independently of site features) and site-driven (site features preclude the species' presence, independently of its traits). DD affinity (DDA) is a measure of species' tendencies to be absent from sites that they could inhabit or of sites' tendencies to lack species that could be present.
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