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The Spread of Lone Star Ticks () and Persistence of Blacklegged Ticks () on a Coastal Island in Massachusetts, USA.
Insects
September 2024
Laboratory of Medical Zoology, Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA.
Article Synopsis
- The lone star tick's range has increased in the northeastern USA, now overlapping with the blacklegged tick, which carries serious diseases like Lyme disease.
- Research on Martha's Vineyard from 2011 to 2024 showed the expansion of lone star ticks from certain areas to all six towns, coinciding with more tick submissions for pathogen testing.
- While blacklegged ticks were slightly more common in wooded areas, lone star ticks were found in a broader variety of habitats, complicating prevention and management efforts for the public.
Host-pathogen associations inferred from bloodmeal analyses of ticks in a low biodiversity setting.
Appl Environ Microbiol
September 2024
Department of Ecology, Evolution, and Environmental Biology, Columbia University, New York, New York, USA.
Unlabelled: Tick-borne pathogen emergence is dependent on the abundance and distribution of competent hosts in the environment. ticks are generalist feeders, and their pathogen infection prevalence depends on their relative feeding on local competent and non-competent hosts. The ability to determine what host a larval life stage tick fed on can help predict infection prevalence, emergence, and spread of certain tick-borne pathogens and the risks posed to public health.
View Article and Find Full Text PDFBabesiosis in immunosuppressed hosts: pathogenesis, diagnosis and management.
Curr Opin Infect Dis
October 2024
Harvard Medical School, Massachusetts General Hospital, Infectious Disease Division, Boston, Massachusetts, USA.
Article Synopsis
- This review highlights the growing challenges of managing babesiosis in immunocompromised individuals, particularly in light of climate change expanding its reach.
- Immunocompromised patients, especially those without spleens or with B-cell defects, face a higher risk of severe and recurrent babesiosis, and resistance to standard treatments like azithromycin and atovaquone is emerging.
- There is a need for improved methods to study treatment resistance and to develop more effective therapies for patients with resistant infections, as babesiosis is expected to become a more common complication in these populations.
Identification of immunoreactive antigens by phage display cDNA screen.
Infect Immun
July 2024
Department of Developmental, Molecular, and Chemical Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.
Human babesiosis is a malaria-like illness caused by protozoan parasites of the genus . is responsible for most cases of human babesiosis in the United States, particularly in the Northeast and the Upper Midwest. is primarily transmitted to humans through the bite of infected deer ticks but also through the transfusion of blood components, particularly red blood cells.
View Article and Find Full Text PDFTafenoquine for Relapsing Babesiosis: A Case Series.
Clin Infect Dis
July 2024
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Boston, Massachusetts, USA.
Background: Relapsing babesiosis often occurs in highly immunocompromised patients and has been attributed to the acquisition of resistance against drugs commonly used for treatment such as atovaquone, azithromycin, and clindamycin. Tafenoquine, which is approved for malaria prophylaxis and presumptive antirelapse treatment of Plasmodium vivax malaria, has shown activity against Babesia microti in several animal models of acute infection and in a single human case of relapsing babesiosis. Here, we report 5 cases of relapsing babesiosis treated with tafenoquine, including the previous case, and begin to define the conditions for optimal use of tafenoquine in relapsing babesiosis.
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