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Thymol inhibits ergosterol biosynthesis in Nakaseomyces glabratus, but differently from azole antifungals.
J Mycol Med
December 2024
Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran; Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:
Introduction: Nakaseomyces glabratus is considered a high priority of attention according to WHO, and also is an important yeast species due to its high rate of intrinsic/acquired resistance against fluconazole. This study aimed at the possible mechanisms of action of thymol, as the promising new antifungal agent, in N. glabratus.
View Article and Find Full Text PDFHybrid Feature Extractor Using Discrete Wavelet Transform and Histogram of Oriented Gradient on Convolutional-Neural-Network-Based Palm Vein Recognition.
Sensors (Basel)
January 2024
Department of Electrical Engineering, Universitas Indonesia, Depok 16424, Jawa Barat, Indonesia.
Biometric recognition techniques have become more developed recently, especially in security and attendance systems. Biometrics are features attached to the human body that are considered safer and more reliable since they are difficult to imitate or lose. One of the popular biometrics considered in research is palm veins.
View Article and Find Full Text PDFOverproduction of mycotoxin biosynthetic enzymes triggers Fusarium toxisome-shaped structure formation via endoplasmic reticulum remodeling.
PLoS Pathog
January 2024
State Key Laboratory of Rice Biology, Key Laboratory of Biology of Crop Pathogens and Insects, Institute of Biotechnology, Zhejiang University, Hangzhou, People's Republic of China.
Mycotoxin deoxynivalenol (DON) produced by the Fusarium graminearum complex is highly toxic to animal and human health. During DON synthesis, the endoplasmic reticulum (ER) of F. graminearum is intensively reorganized, from thin reticular structure to thickened spherical and crescent structure, which was referred to as "DON toxisome".
View Article and Find Full Text PDFDirect ionic stress sensing and mitigation by the transcription factor NFAT5.
bioRxiv
September 2023
Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Homeostatic control of intracellular ionic strength is essential for protein, organelle and genome function, yet mechanisms that sense and enable adaptation to ionic stress remain poorly understood in animals. We find that the transcription factor NFAT5 directly senses solution ionic strength using a C-terminal intrinsically disordered region. Both in intact cells and in a purified system, NFAT5 forms dynamic, reversible biomolecular condensates in response to increasing ionic strength.
View Article and Find Full Text PDFMulti-center sparse learning and decision fusion for automatic COVID-19 diagnosis.
Appl Soft Comput
January 2022
National- Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to a sharp increase in hospitalized patients with multi-organ disease pneumonia. Early and automatic diagnosis of COVID-19 is essential to slow down the spread of this epidemic and reduce the mortality of patients infected with SARS-CoV-2. In this paper, we propose a joint multi-center sparse learning (MCSL) and decision fusion scheme exploiting chest CT images for automatic COVID-19 diagnosis.
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