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The Neisseria meningitidis urethritis clade (NmUC) acts as a "chimeric pathogen" during infection of primary, human male, urethral epithelial cells.
J Infect Dis
December 2024
Center for Microbial Pathogenesis, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio 43205 USA.
Background: Clusters of male urethritis cases, caused by a novel clade of non-groupable Neisseria meningitidis (NmUC, "the clade"), have been reported globally. Genetic features unique to NmUC isolates include: the acquisition of the gonococcal denitrification loci, norB-aniA; a unique factor H binding protein (fHbp) variant; and loss of group C capsule and intrinsic lipooligosaccharide sialylation. We hypothesized that these characteristics might confer a colonization and survival advantage to NmUC during male urethral infection relative to non-clade group C Neisseria meningitidis.
View Article and Find Full Text PDFExperimental genital tract infection demonstrates Neisseria gonorrhoeae MtrCDE efflux pump is not required for in vivo human infection and identifies gonococcal colonization bottleneck.
PLoS Pathog
September 2024
Division of Infectious Diseases, Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina, United States.
Article Synopsis
- The MtrCDE efflux pump in Neisseria gonorrhoeae is known to export various antimicrobial compounds and is recognized as a virulence factor.
- A study on strain FA1090 showed that this pump is not necessary for establishing infection in the human male urethra, contrasting with findings in female mice, where a related strain showed reduced fitness without the pump.
- Further experiments indicated that the advantage conferred by the MtrCDE pump varies between strains, highlighting a unique colonization dynamic in the human male urethra that may inform future research on gonorrhea infections and their management.
Cyclization increases bactericidal activity of arginine-rich cationic cell-penetrating peptide for .
Microbiol Spectr
September 2024
Department of Laboratory Medicine, University of California San Francisco, San Francisco, California, USA.
We previously reported that a linear cationic 12-amino acid cell-penetrating peptide (CPP) was bactericidal for . In this study, our objectives were to determine the effect of cyclization of the linear CPP on its antibacterial activity for and cytotoxicity for human cells. We compared the bactericidal effect of 4-hour treatment with the linear CPP to that of CPPs cyclized by a thioether or a disulfide bond on human challenge and multi-drug resistant (MDR) strains of grown in cell culture media with 10% fetal bovine serum (FBS).
View Article and Find Full Text PDFDetection of CTX-M-15 ESBL in XDR Haemophilus parainfluenzae from a urethral swab.
J Antimicrob Chemother
March 2024
Université de Paris Cité, INSERM, IAME, Paris F-75018, France.
Objectives: Haemophilus parainfluenzae is an opportunistic pathogen causing respiratory tract infection and sexually transmitted diseases. The emergence of multidrug resistance in this species is particularly worrisome, especially since the recent description of CTX-M-15 ESBL-producing isolates in Spain. The aim of this study was to characterize a CTX-M-15-producing H.
View Article and Find Full Text PDFantimicrobial susceptibility trends in Bangkok, Thailand, 2015-21: Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP).
JAC Antimicrob Resist
December 2023
Department of Global HIV, Hepatitis and STI Programmes, World Health Organization, Geneva, Switzerland.
Objectives: Rising antimicrobial resistance (AMR) in is a global public health concern. Many ceftriaxone-resistant cases have been linked to Asia. In the WHO/CDC global Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP), we conducted AMR surveillance at two clinical sites in Bangkok, Thailand, 2015-21.
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